by Shanhui Ren, Zaib Ur Rehman, Bo Gao, Zengqi Yang, Jiyong Zhou, Chunchun Meng, Cuiping Song, Venugopal Nair, Yingjie Sun, Chan Ding Deoxyribonucleic acid (DNA) damage response (DDR) is the fundamental cellular response for maintaining genomic integrity and suppressing tumorigenesis. The activation of ataxia telangiectasia-mutated (ATM) kinase is central to DNA double-strand break (DSB) for maintaining host-genome integrity in mammalian cells. Oncolytic Newcastle disease virus (NDV) can selectively...
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by Visnu Chaparro, Louis-Philippe Leroux, Laia Masvidal, Julie Lorent, Tyson E. Graber, Aude Zimmermann, Guillermo Arango Duque, Albert Descoteaux, Tommy Alain, Ola Larsson, Maritza Jaramillo The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a chronic infection which is fatal when untreated. Herein, we investigated whether in addition to altering transcription, L. donovani modulates host mRNA translation to establish a successful infection. Polysome-profiling...
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Abstract Aim Although many prominent ear deformity (PED) surgery techniques have been described to date, there have been few comprehensive studies evaluating the recurrence rates in different age groups. Previous studies have focused either on the young or the elderly. The present clinical study compares recurrence rates among patients of different age groups undergoing PED repair and discusses cartilage morphology. ...
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Publication date: Available online 31 May 2020Source: Translational ResearchAuthor(s): Dharam Kaushik, Keith A. Ashcraft, Hanzhang Wang, Karthigayan Shanmugasundaram, Pankil Shah, Gabriela Gonzalez, Alia Nazarullah, Cooper B. Tye, Michael A. Liss, Deepak Pruthi, Ahmed M. Mansour, Wasim Chowdhury, Dean Bacich, Hao Zhang, Amanda L. Watson, Karen Block, Denise O'Keefe, Ronald Rodriguez
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BackgroundPrimary ovarian insufficiency (POI) affects 1% of women under 40 years and is a public health problem. The genetic causes of POI are highly heterogeneous with isolated or syndromic forms. Recently, variants in genes involved in DNA repair have been shown to cause POI. Notably, syndromic POI with Fanconi anaemia (FA) traits related to biallelic BRCA2 truncated variants has been reported. Here, we report a novel phenotype of isolated POI with a BRCA2 variant in a consanguineous Turkish family.MethodsExome...
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BackgroundPathogenic variants in the CDKN2A gene are generally associated with the development of melanoma and pancreatic ductal adenocarcinoma (PDAC), but specific genotype-phenotype correlations might exist and the extent of PDAC risk is not well established for many variants.MethodsUsing the Dutch national familial melanoma database, we identified all families with a pathogenic CDKN2A variant and investigated the occurrence of PDAC within these families. We also estimated the standardised incidence...
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ACS NanoDOI: 10.1021/acsnano.0c03131
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ACS NanoDOI: 10.1021/acsnano.0c03167
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A new NHS centre to investigate the effects of race and ethnicity on people’s health has got the go ahead after a special issue of The BMJ in February focused on the continuing problem of racism in...
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Nearly a third of doctors have reported that mental health conditions linked to their work —such as anxiety, depression, and burnout—have been made worse by the covid-19 pandemic, a survey by the BMA...
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A group of prominent women’s health organisations are suing the Food and Drug Administration (FDA) for preventing telemedicine prescribing of mifepristone, one of the drugs used in early abortions...
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Central and South America are fast becoming major centres of the covid-19 pandemic as cases surge in Brazil, Peru, Mexico, Chile, and, to an unknown extent, Venezuela and Nicaragua.With 514 849...
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Khunti and colleagues discuss the possible association between ethnicity and severity of covid-19.1 Our experience in London would suggest such a link, and further analysis of clinical outcomes data...
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In a recent article in Medical Humanities, Sharpe and Greco characterise myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as an ‘illness without disease’, citing the absence of identified diagnostic markers. They attribute patients’ rejection of psychological and behavioural interventions, such as cognitive–behavioural therapy (CBT) and graded exercise therapy (GET), to a ‘paradox’ resulting from a supposed failure to acknowledge that ‘there is no good objective evidence of bodily disease’....
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Cancers, Vol. 12, Pages 1444: Impact of CD56 Continuously Recognizable as Prognostic Value of Acute Promyelocytic Leukemia: Results of Multivariate Analyses in the Japan Adult Leukemia Study Group (JALSG)-APL204 Study and a Review of the Literature Cancers doi: 10.3390/cancers12061444 Authors: Takeshita Asou Atsuta Furumaki Sakura Ueda Sawa Dobashi Taniguchi Suzuki Nakagawa Tamaki Hagihara Fujimaki Minamiguchi Fujita...
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ObjectivePatient ownership of disease is vital in rare diseases like primary biliary cholangitis (PBC). This survey of UK members of the PBC foundation aimed to assess patients’ perception of their disease management, focusing on key biomarkers and problematic symptoms.DesignRegistered PBC foundation members were surveyed on their experiences on their most recent clinic visit, covering the type of hospital and clinician and whether biochemical response and symptom burden were discussed, including...
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ObjectiveTo determine if age is a factor in a patients’ likelihood of breaching the 4 hour time target to admission/discharge in emergency departments (EDs) within NHS Scotland.MethodsWe used data from the Information Service Division Scotland to analyse all ED attendances in Scotland between January 2015 and September 2018 (n=5 596 642). We assessed the likelihood of time to admission/discharge being within 4 hours, 8 hours and 12 hours for all age categories (reference category 20 to 24 years)....
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Given the high risk of healthcare worker (HCW) infection with COVID-19 during aerosol-generating medical procedures, the use of a box barrier during intubation for protection of HCWs has been examined. Previous simulation work has demonstrated its efficacy in protecting HCWs from cough-expelled droplets. Our objective was to assess its ability to protect HCWs against aerosols generated during aerosol-generating medical procedures. We used a battery-powered vapouriser to assess movement of vapour...
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Publication date: Available online 31 May 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): L de Gabory, A. Alharbi, M. Kérimian, M.-E. Lafon
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This Viewpoint proposes a policy framework for reopening of US primary, middle, and high schools (kindergarten through 12th grade) in fall 2020, including ramping up community public health responses in the summer, symptom screening of students, and privileging return-to-school decisions for younger children and others at risk for education disparities.
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In the context of potential aerosol spread of SARS-CoV-2 infection, this Viewpoint argues for use of upper-room germicidal UV (GUV) fixtures as a means to disinfect circulating air and prevent spread of COVID-19 and other infections in health care settings.
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The early age of sexual initiation contribute a lot for various risks such as mistimed pregnancy followed by insecure termination, developing fistula and contracting sexually transmitted infections which are c...
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Publication date: Available online 31 May 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Ângela Reis-Rego, João Almeida, João Lino
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COVID-19 has laid bare the need to reconsider the hope and money we invest in genetics research. -- Read more on ScientificAmerican.com
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A new NHS centre to investigate the effects of race and ethnicity on people’s health has got the go ahead after a special issue of The BMJ in February focused on the continuing problem of racism in...
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Nearly a third of doctors have reported that mental health conditions linked to their work —such as anxiety, depression, and burnout—have been made worse by the covid-19 pandemic, a survey by the BMA...
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27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: quality of care These pubmed results were generated on 2020/06/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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JFB, Vol. 11, Pages 36: Substituted Nano-Hydroxyapatite Toothpastes Reduce Biofilm Formation on Enamel and Resin-Based Composite Surfaces Journal of Functional Biomaterials doi: 10.3390/jfb11020036 Authors: Andrei C. Ionescu Gloria Cazzaniga Marco Ottobelli Franklin Garcia-Godoy Eugenio Brambilla Background: Toothpastes containing nano-hydroxyapatite (n-HAp) substituted with metal ions provide calcium and phosphate ions to dental hard tissues, reducing demineralization,...
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Cancers, Vol. 12, Pages 1443: Biomarker Panel for the Diagnosis of Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12061443 Authors: Hongbeom Kim Kyung Nam Kang Yong Sung Shin Yoonhyeong Byun Youngmin Han Wooil Kwon Chul Woo Kim Jin-Young Jang A single tumor marker has a low diagnostic value in pancreatic cancer. Combinations of multiple biomarkers and unique analysis algorithms can be applied to overcome these limitations. This study sought...
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Cancers, Vol. 12, Pages 1439: SPON2 Is Upregulated through Notch Signaling Pathway and Promotes Tumor Progression in Gastric Cancer Cancers doi: 10.3390/cancers12061439 Authors: Hyeon-Gu Kang Won-Jin Kim Myung-Giun Noh Kyung-Hee Chun Seok-Jun Kim Spondin-2 (SPON2) is involved in cancer progression and metastasis of many tumors; however, its role and underlying mechanism in gastric cancer are still obscure. In this study, we investigated the role of SPON2 and related...
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Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Kevin Campbell, Arlene Naranjo, Emily Hibbitts, Julie M. Gastier-Foster, Rochelle Bagatell, Meredith S. Irwin, Hiroyuki Shimada, Michael Hogarty, Julie R. Park, Steven G. DuBois
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