IgE-mediated food allergy (FA) accounts for the leading cause of anaphylaxis in children, though fatal reactions remain rare.1,2,3 Strict adherence to avoidance diets and use of FA emergency management plans can decrease reaction rates significantly, with one study demonstrating a 60-fold reduced frequency of severe FA reactions.4 However, which patients experience severe vs mild symptoms, as well as contributory factors, remains an area of active study.5,6 Currently, no unified definition of a severe...
Mon Jun 01, 2020 03:00
Matthew Greenhawt is supported by grant #5K08HS024599-02 from the Agency for Healthcare Research and Quality; is an expert panel and coordinating committee member of the NIAID-sponsored Guidelines for Peanut Allergy Prevention; has served as a consultant for the Canadian Transportation Agency, Thermo Fisher, Intrommune, and Aimmune Therapeutics; is a member of physician/medical advisory boards for Aimmune Therapeutics, DBV Technologies, Sanofi/Genzyme, Genentech, Nutricia, Kaleo Pharmaceutical, Nestle,...
Mon Jun 01, 2020 03:00
Related ArticlesDiurnal Regulation of Peripheral Glucose Metabolism: Potential Effects of Exercise Timing. Obesity (Silver Spring). 2020 May 31;: Authors: Mancilla R, Krook A, Schrauwen P, Hesselink MKC Abstract Diurnal oscillations in energy metabolism are linked to the activity of biological clocks and contribute to whole-body glucose homeostasis. Postprandially, skeletal muscle takes up approximately 80% of circulatory glucose and hence is a key organ...
Mon Jun 01, 2020 15:14
Related ArticlesNeuronal deficiency of p38α-MAPK ameliorates symptoms and pathology of APP or Tau-transgenic Alzheimer's mouse models. FASEB J. 2020 May 31;: Authors: Schnöder L, Gasparoni G, Nordström K, Schottek A, Tomic I, Christmann A, Schäfer KH, Menger MD, Walter J, Fassbender K, Liu Y Abstract Alzheimer's disease (AD) is the leading cause of dementia with very limited therapeutic options. Amyloid β (Aβ) and phosphorylated Tau (p-Tau) are key pathogenic...
Mon Jun 01, 2020 15:14
Related ArticlesTranscriptional activity of vitamin D receptor in human periodontal ligament cells is diminished under inflammatory conditions. J Periodontol. 2020 May 31;: Authors: Blufstein A, Behm C, Kubin B, Gahn J, Moritz A, Rausch-Fan X, Andrukhov O Abstract BACKGROUND: Although vitamin D3 deficiency is considered as a risk factor for periodontitis, supplementation during periodontal treatment has not been shown to be beneficial so far. Human periodontal...
Mon Jun 01, 2020 15:14
Related ArticlesImproved Isolation of Human Vascular Wall-Resident Mesenchymal Stem Cells. Methods Mol Biol. 2020;2155:71-81 Authors: Klein D Abstract Niches for tissue-resident mesenchymal stem cells (MSCs) have been identified in many adult tissues. In particular, MSCs residing in the vascular stem cell niche came into focus: the so-called vascular wall-resident MSCs (VW-MSCs) were, based upon their anatomic location, (1) distributed throughout the...
Mon Jun 01, 2020 15:14
ARTP mutation and adaptive laboratory evolution improve probiotic performance of Bacillus coagulans.
Related ArticlesARTP mutation and adaptive laboratory evolution improve probiotic performance of Bacillus coagulans. Appl Microbiol Biotechnol. 2020 May 30;: Authors: Liu K, Fang H, Cui F, Nyabako BA, Tao T, Zan X, Chen H, Sun W Abstract Bacillus coagulans is a thermophilic, facultative anaerobic, spore-forming Gram-positive bacterium, which is used as a probiotic in animal feed and human dietary supplements. In the present study, a bile-resistant thermophilic...
Mon Jun 01, 2020 15:14
Related ArticlesA Systematic Review on Cornea Epithelial-Stromal Homeostasis. Ophthalmic Res. 2020 May 29;: Authors: Wong HL, Poon SHL, Bu Y, Lo ACY, Jhanji V, Chan YK, Shih KC Abstract Introduction This review aims to summarise the role of different cells, genes, proteins and lipid in regulating cornea epithelial-stromal homeostasis. Methods We performed an Entrez PubMed literature search using keywords 'human', 'cornea', 'epithelial', 'stromal', 'homeostasis',...
Mon Jun 01, 2020 15:14
Related ArticlesPersistent idiopathic hyperphosphatasemia from bone alkaline phosphatase in a healthy boy. Bone. 2020 May 28;:115459 Authors: Whyte MP, Ma NS, Mumm S, Gottesman GS, McAlister WH, Nenninger AR, Bijanki VN, Ericson KL, Magnusson P Abstract Alkaline phosphatase (ALP) in humans comprises a family of four cell-surface phosphomonoester phosphohydrolase isozymes. Three genes separately encode the "tissue-specific" ALPs whereas the fourth gene...
Mon Jun 01, 2020 15:14
Related ArticlesImpact of metformin on immunological markers: Implication in its anti-tumor mechanism. Pharmacol Ther. 2020 May 28;:107585 Authors: Chen GG, Woo PYM, Ng SCP, Wong GKC, Chan DTM, van Hasselt CA, Tong MCF, Poon WS Abstract Metformin, an anti-hyperglycemic drug, has been known to have antitumor properties for around 15 years. Although there are a number of reports attributing the antitumor function of metformin to its impact on energy homeostasis...
Mon Jun 01, 2020 15:14
Publication date: Available online 1 June 2020Source: World NeurosurgeryAuthor(s): Matteo de Notaris, Francesco Corrivetti, Giuseppe Catapano
Mon Jun 01, 2020 15:10
Related ArticlesCigarette smoking and smokeless tobacco use among male south Asian migrants in the United Arab Emirates: a cross-sectional study. BMC Public Health. 2020 May 30;20(1):815 Authors: Ali R, Loney T, Al-Houqani M, Blair I, Aziz F, Al Dhaheri S, El Barazi I, Soteriades ES, Shah SM Abstract BACKGROUND: Few data were available on smoking and smokeless tobacco use in South Asian migrants in the United Arab Emirates (UAE). This study aimed to...
Mon Jun 01, 2020 15:09
Related ArticlesData-sharing recommendations in biomedical journals and randomised controlled trials: an audit of journals following the ICMJE recommendations. BMJ Open. 2020 May 30;10(5):e038887 Authors: Siebert M, Gaba JF, Caquelin L, Gouraud H, Dupuy A, Moher D, Naudet F Abstract OBJECTIVE: To explore the implementation of the International Committee of Medical Journal Editors (ICMJE) data-sharing policy which came into force on 1 July 2018 by ICMJE-member...
Mon Jun 01, 2020 15:06
Related ArticlesDocumenting the untold histories of late-diagnosed autistic adults: a qualitative study protocol using oral history methodology. BMJ Open. 2020 May 30;10(5):e037968 Authors: Pellicano E, Lawson W, Hall G, Mahony J, Lilley R, Davis C, Arnold S, Trollor J, Yudell M Abstract INTRODUCTION: Receiving a diagnosis of autism in adulthood is increasingly common for a subset of individuals who were either misdiagnosed in childhood or missed out...
Mon Jun 01, 2020 15:06
Related ArticlesStudy protocol to examine the relationship between environmental exposure to lead and blood lead levels among children from day-care centres in Ekurhuleni Metropolitan Municipality. BMJ Open. 2020 May 30;10(5):e036687 Authors: Cindi MD, Mbonane TP, Naicker N Abstract INTRODUCTION: Lead exposure is toxic to all humans and is very harmful to young children, especially 5-year-olds. Elevated blood lead levels (BLLs) in children have been...
Mon Jun 01, 2020 15:06
Related ArticlesImproving quality of surgical and anaesthesia care at hospital level in sub-Saharan Africa: a systematic review protocol of health system strengthening interventions. BMJ Open. 2020 May 30;10(5):e036615 Authors: Brima N, Davies J, Leather AJ Abstract INTRODUCTION: Over 5 billion people in the world do not have access to safe, affordable surgical and anaesthesia care when needed. In order to improve health outcomes in patients with surgical...
Mon Jun 01, 2020 15:06
Related ArticlesCohort profile: the Singapore diabetic cohort study. BMJ Open. 2020 May 30;10(5):e036443 Authors: Luo M, Tan LWL, Sim X, Ng MKH, Van Dam R, Tai ES, Chia KS, Tang WE, Seah DE, Venkataraman K Abstract PURPOSE: The diabetic cohort (DC) was set up to study the determinants of complications in individuals with type 2 diabetes and examine the role of genetic, physiological and lifestyle factors in the development of complications in these individuals....
Mon Jun 01, 2020 15:06
Related ArticlesPhenomenological study of medical interns reflecting on their experiences, of open disclosure communication after medication error: linking rationalisation to the conscious competency matrix. BMJ Open. 2020 May 30;10(5):e035647 Authors: Lane AS, Roberts C Abstract INTRODUCTION AND OBJECTIVES: Errors are common within healthcare, especially those involving the prescribing of medications. Open disclosure is a policy stating doctors should...
Mon Jun 01, 2020 15:06
Related ArticlesDevelopment and evaluation of a patient-centred program for low anterior resection syndrome: protocol for a randomized controlled trial. BMJ Open. 2020 May 30;10(5):e035587 Authors: Garfinkle R, Loiselle CG, Park J, Fiore JF, Bordeianou LG, Liberman AS, Morin N, Faria J, Ghitulescu G, Vasilevsky CA, Bhatnagar SR, Boutros M Abstract INTRODUCTION: Low anterior resection syndrome (LARS) is described as disordered bowel function after rectal...
Mon Jun 01, 2020 15:06
Related ArticlesCharacteristics and interpretation of subgroup analyses based on tumour characteristics in randomised trials testing target-specific anticancer drugs: design of a systematic survey. BMJ Open. 2020 May 30;10(5):e034565 Authors: Schandelmaier S, Schmitt AM, Herbrand AK, Glinz D, Ewald H, Briel M, Guyatt GH, Hemkens LG, Kasenda B Abstract BACKGROUND: Target-specific anticancer drugs are under rapid development. Little is known, however,...
Mon Jun 01, 2020 15:06
Related ArticlesHistorical database cohort study addressing the clinical patterns prior to idiopathic pulmonary fibrosis (IPF) diagnosis in UK primary care. BMJ Open. 2020 May 30;10(5):e034428 Authors: Thickett D, Voorham J, Ryan R, Jones R, Coker R, Wilson AM, Yang S, Ow MY, Raju P, Chaudhry I, Hardjojo A, Carter V, Price DB Abstract OBJECTIVE: To explore the clinical pathways, including signs and symptoms, and symptom progression patterns preceding...
Mon Jun 01, 2020 15:06
Related ArticlesHas the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study. BMJ Open. 2020 May 30;10(5):e033357 Authors: Alfirevic A, Downing J, Daras K, Comerford T, Pirmohamed M, Barr B Abstract OBJECTIVE: There is concern about long-term safety of direct oral coagulants (DOACs) in clinical practice. Our aim was to investigate whether the introduction...
Mon Jun 01, 2020 15:06
Related ArticlesPopulation Registry of Esophageal and Stomach Tumours in Ontario (PRESTO): protocol for a multicentre clinical and pathological database including 25 000 patients. BMJ Open. 2020 May 30;10(5):e032729 Authors: Gupta V, Levy J, Allen-Ayodabo C, Amirazodi E, Davis L, Li Q, Mahar A, Coburn NG, PRESTO Study Investigators Abstract INTRODUCTION: Oesophagogastric cancers carry a high mortality, economic burden and rising incidence. There is a...
Mon Jun 01, 2020 15:06
Related Articles'Building on shaky ground'-challenges to and solutions for primary care guideline implementation in four provinces in South Africa: a qualitative study. BMJ Open. 2020 May 30;10(5):e031468 Authors: Kredo T, Cooper S, Abrams AL, Muller J, Schmidt BM, Volmink J, Atkins S Abstract OBJECTIVES: Clinical guidelines support evidence-informed quality patient care. Our study explored perspectives of South African subnational health managers regarding...
Mon Jun 01, 2020 15:06
Related ArticlesPersonalized Preoperative Nomograms Predicting Postoperative Risks after Resection of Perihilar Cholangiocarcinoma. World J Surg. 2020 May 30;: Authors: Golse N, Nunez J, Mazzotta A, Cano L, Bergeat D, Sulpice L, Jeddou H, Abdelrafee A, Sa Cunha A, Cherqui D, Adam R, Boudjema K, Vibert E Abstract INTRODUCTION: Curative treatment of perihilar tumors requires major hepatectomy responsible for high morbidity and mortality. Current nomograms...
Mon Jun 01, 2020 15:01
Related ArticlesProvider-patient Language Discordance and Cancer Operations: Outcomes from a Single Center Linked to a State Vital Statistics Registry. World J Surg. 2020 May 30;: Authors: Feeney T, Park C, Godley F, Cassidy M, Sachs T, McAneny D, Tseng JF, Drake FT Abstract INTRODUCTION: Patterns of worldwide immigration have resulted in high rates of discordance between medical providers and the patients they treat. For example, in the USA, 25 million...
Mon Jun 01, 2020 15:01
Related ArticlesLetter to the Editor: Prognostic Impact of Osteopenia in Patients Who Underwent Living Donor Liver Transplantation for Hepatocellular Carcinoma. World J Surg. 2020 May 30;: Authors: Akbulut S, Sahin TT, Yilmaz S PMID: 32474626 [PubMed - as supplied by publisher]
Mon Jun 01, 2020 15:01
Related ArticlesVascular Anatomy of Mesopancreas in Pancreatoduodenectomy Using an Intestinal Derotation Procedure. World J Surg. 2020 May 30;: Authors: Sugiyama M, Suzuki Y, Nakazato T, Yokoyama M, Kogure M, Matsuki R, Abe N Abstract BACKGROUND: Mesopancreas excision in pancreatoduodenectomy is technically complicated because of the anatomical complexity of the mesopancreas with the inferior peripancreatic blood vessels which is caused by intestinal...
Mon Jun 01, 2020 15:01
Related ArticlesEffect of Surgical Approach on Node Harvest in Gastrectomy: Analysis of the National Cancer Database. World J Surg. 2020 May 30;: Authors: Watson MD, Trufan S, Benbow JH, Gower NL, Hill JS, Salo JC Abstract BACKGROUND: Gastrectomy is the cornerstone of treatment for gastric cancer. Recent studies demonstrated significant surgical outcome advantages for patients undergoing minimally invasive versus open gastrectomy. Lymph node harvest...
Mon Jun 01, 2020 15:01
Successful treatment of CCR4+ mycosis fungoides palmaris et plantaris with mogamulizumab monotherapy
Sun May 31, 2020 22:42
Abstract A new type of coronavirus family (SARS‐CoV‐2), which can be found in humans and animals, with many varieties and clinical symptoms, was first seen in Wuhan, China in late 2019, under the name novel Coronavirus Disease 2019 (COVID‐19). In the literature, cutaneous symptoms related to the disease are generally emphasized. However, it is not yet known whether this new SARS‐CoV‐2 virus, which has entered our lives, plays a role in the etiopathogenesis of dermatological diseases. The patients...
Sun May 31, 2020 22:32
Sun May 31, 2020 15:34
Abstract Vitiligo is a systemic disease that affects not only the skin but also other areas that contain melanocytes, such as the inner ear. Studies of the effect of vitiligo on hearing loss have shown inconsistent results, and it is not clear which parameters related to the disease affect hearing. The aim of this study was to determine which disease‐related parameters trigger damage to cochlear melanocytes in vitiligo patients and the effect of vitiligo on the outer hair cells and hearing. Thirty‐one...
Sun May 31, 2020 15:29
Sun May 31, 2020 15:29
Sun May 31, 2020 15:24
ABSTRACT Introduction Hydrogels based on hyaluronic acid are used to restore volume, hydration and skin tone, as well as to correct scars, asymmetries or defects of the soft tissue. Hyaluronic acid is often chemically crosslinked with different crosslinking agents in order to improve its mechanical and biological properties. Here we focused on defining the chemical and mechanical characterization of a new hydrogel with specific characteristics: hyaluronic acid polyethylene glycol (PEG)‐crosslinked...
Sun May 31, 2020 14:48
Abstract Recently there is a surge in cosmetic and aesthetic surgery procedures. Several patient seeking various cosmetics procedures present to aesthetic surgery clinics and demanding procedures which are out of proportion. Several of these patients have under‐recognized or untreated psychiatric disorders. Proper screening and evaluation of these patients could save money and resources. This brief review focuses on current trends, clinical and psychological assessment and expectations on the part...
Sun May 31, 2020 11:00
Related ArticlesFibrous dysplasia limited to an ossicle. Auris Nasus Larynx. 2020 May 27;: Authors: Jung JY, Lee MY Abstract Fibrous dysplasia is an unusual pathologic condition caused by abnormal bone metabolism. Temporal bone involvement is often seen, but it is uncommon to find fibrous dysplasia limited to the middle ear, especially originating in and confined to a single ossicle. Here we report a case of osteofibrous dysplasia limited exclusively...
Mon Jun 01, 2020 14:51
Related ArticlesCoronaviridae - old friends, new enemy! Oral Dis. 2020 May 31;: Authors: Carneiro Leão J, Paula de Lima Gusmão T, Machado Zarzar A, Leão Filho JC, Barkokebas Santos de Faria A, Morais Silva IH, Gueiros LAM, Robinson NA, Porter S, de Albuquerque Tavares Carvalho A Abstract Coronaviridae is a family of single-stranded positive enveloped RNA viruses. This article aimed to review the history of these viruses in the last 60 years since...
Mon Jun 01, 2020 14:36
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