Beta-cell cholecystokinin expression in obese mice promoted pancreatic ductal adenocarcinoma (PDAC).
Mon Jun 01, 2020 10:05
Autophagy-mediated MHC-I degradation facilitated immune evasion in pancreatic ductal adenocarcinoma.
Mon Jun 01, 2020 10:05
Lori L. Pierce, MD; George D. Demetri, MD; and Pasi A. Jänne, MD, PhD, are featured.
Mon Jun 01, 2020 10:05
MYC altered Epstein–Barr virus (EBV) chromatin structure to maintain latency in Burkitt lymphoma.
Mon Jun 01, 2020 10:05
According to results from an ongoing phase I trial, the novel immune checkpoint inhibitor COM701, which targets PVRIG, has shown early signs of efficacy, on its own and combined with nivolumab, in patients with a variety of advanced solid tumors.
Mon Jun 01, 2020 10:05
Summary:Most patients with pancreatic cancer who undergo curative resection and systemic chemotherapy still relapse with local or systemic recurrence. In this issue, Sakamoto and colleagues use advanced genomic tools to investigate the evolutionary origins of pancreatic cancer recurrence and discover an increased mutational burden that might be promoted by therapeutic intervention and might provide an opportunity for therapeutic intervention. See related article by Sakamoto et al., p. 792.
Mon Jun 01, 2020 10:05
Matching patients with pancreatic cancer to therapies based on genomic alterations in their tumors may be beneficial. In the retrospective Know Your Tumor trial, patients with alterations who were treated with targeted agents lived longer than those treated with standard therapies.
Mon Jun 01, 2020 10:05
Summary:Tumor cells maintain a reverse pH gradient relative to normal cells, conferring cell-intrinsic and cell-extrinsic benefits that sustain tumor growth. In this issue of Cancer Discovery, Galenkamp and colleagues reveal that NHE7 mediates acidification of the trans-Golgi network in pancreatic ductal adenocarcinoma, which is critical for the maintenance of cytosolic pH and consequently tumor growth. See related article by Galenkamp et al., p. 822.
Mon Jun 01, 2020 10:05
Lung cancer likelihood in plasma, or Lung-CLiP, developed using machine learning, is a liquid-biopsy method being studied for early detection of lung cancer with the hope of increasing screening rates and patient survival.
Mon Jun 01, 2020 10:05
Summary:Cytokine release and macrophage activation contribute to immunopathology after SARS-CoV-2 infection. We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy.
Mon Jun 01, 2020 10:05
GC027, a new chimeric antigen receptor T-cell therapy manufactured with a proprietary allogeneic platform, TruUCAR, has shown effectiveness in a handful of patients with relapsed/refractory T-cell acute lymphoblastic leukemia, a disease with limited treatment options.
Mon Jun 01, 2020 10:05
The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally more vulnerable to infections, systematic analysis of diverse cohorts of patients with cancer affected by COVID-19 is needed. We performed a multicenter study including 105 patients with cancer and 536 age-matched noncancer patients confirmed with COVID-19. Our results showed COVID-19 patients with cancer had higher risks in all severe outcomes. Patients...
Mon Jun 01, 2020 10:05
Amid concerns over the spread of COVID-19, oncology practices have "gone virtual," with video appointments scheduled for any service that does not require diagnostic testing or treatment.
Mon Jun 01, 2020 10:05
Although mutations in the gene encoding the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here, we characterize 98 tumors and 12 isogenic cell lines harboring SF3B1 hotspot mutations, identifying hundreds of cryptic 3' splice sites common and specific to different cancer types. Regulatory network analysis revealed that the most common SF3B1 mutation activates MYC via effects conserved across human and mouse...
Mon Jun 01, 2020 10:05
STAG2 encodes a cohesin component and is frequently mutated in myeloid neoplasms, showing highly significant comutation patterns with other drivers, including RUNX1. However, the molecular basis of cohesin-mutated leukemogenesis remains poorly understood. Here we show a critical role of an interplay between STAG2 and RUNX1 in the regulation of enhancer–promoter looping and transcription in hematopoiesis. Combined loss of STAG2 and RUNX1, which colocalize at enhancer-rich, CTCF-deficient sites, synergistically...
Mon Jun 01, 2020 10:05
As the COVID-19 pandemic stretches on, investigators are becoming increasingly concerned about longer-term effects on grants and funding for cancer research. Institutions and philanthropic organizations are especially likely to be hit hard by the economic crisis, with effects that will be particularly acute for early-career investigators.
Mon Jun 01, 2020 10:05
MYC is implicated in the development and progression of pancreatic cancer, yet the precise level of MYC deregulation required to contribute to tumor development has been difficult to define. We used modestly elevated expression of human MYC, driven from the Rosa26 locus, to investigate the pancreatic phenotypes arising in mice from an approximation of MYC trisomy. We show that this level of MYC alone suffices to drive pancreatic neuroendocrine tumors, and to accelerate progression of KRAS-initiated...
Mon Jun 01, 2020 10:05
The coronavirus (COVID-19) is presenting new and unique challenges. We are navigating unchartered waters with this virus, making it important to find new ways to work and interact while also taking care of our mental health and well-being. Many are teleworking full-time for the first time, isolated from co-workers, friends and family. Others are on the front lines caring for others. No matter what, our daily living routines are disrupted causing added anxiety, stress and strain—physically, mentally,...
Mon Jun 01, 2020 07:00
Abstract Objectives Alouatta palliata patterns of growth and sexual dimorphism are evaluated using 20 plus years of field data. Comparisons are made to other species of Alouatta and other New World primates. Materials and methods Records of 92 A. palliata from Guanacaste Province, Costa Rica, were used to generate growth curves for body mass and linear measurements. Timing of growth for the properties was compared, and males and females were contrasted. Slopes and elevations for periods...
Sun May 31, 2020 22:00
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