In the filamentous fungus Neurospora crassa, genes unpaired during meiosis are silenced by a process known as meiotic silencing by unpaired DNA (MSUD). MSUD utilizes common RNA interference (RNAi) proteins, such as Dicer and Argonaute, to target homologous mRNAs for silencing. Previously, we demonstrated that nuclear cap-binding proteins NCBP1 and NCBP2 are involved in MSUD. We report here that SAD-8, a protein similar to human NCBP3, also mediates silencing. Although SAD-8 is not essential for either...
Mon Jun 01, 2020 16:14
The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN) in yeast, fly, and human cells and CENP-A is highly expressed and mislocalized in cancers. Defining mechanisms that prevent mislocalization of CENP-A is an area of active investigation. Ubiquitin-mediated proteolysis of overexpressed Cse4 (GALCSE4)...
Mon Jun 01, 2020 16:14
Understanding the genomic basis of adaptative intraspecific phenotypic variation is a central goal in conservation genetics and evolutionary biology. Lake trout (Salvelinus namaycush) are an excellent species for addressing the genetic basis for adaptive variation because they express a striking degree of ecophenotypic variation across their range; however, necessary genomic resources are lacking. Here we utilize recently-developed analytical methods and sequencing technologies to (1) construct a...
Mon Jun 01, 2020 16:14
Large population-genomic sequencing studies can enable highly-powered analyses of sequence signatures of natural selection. Genome repositories now available for Saccharomyces yeast make it a premier model for studies of the molecular mechanisms of adaptation. We mined the genomes of hundreds of isolates of the sister species S. cerevisiae and S. paradoxus to identify sequence hallmarks of adaptive divergence between the two. From the top hits we focused on a set of genes encoding membrane proteins...
Mon Jun 01, 2020 16:14
Proper nervous system development is required for an organism’s survival and function. Defects in neurogenesis have been linked to neurodevelopmental disorders such as schizophrenia and autism. Understanding the gene regulatory networks that orchestrate neural development, specifically cascades of proneural transcription factors, can better elucidate which genes are most important during early neurogenesis. Neurogenins are a family of deeply conserved factors shown to be both necessary and sufficient...
Mon Jun 01, 2020 16:14
Crossing over, the exchange of DNA between the chromosomes during meiosis, contributes significantly to genetic variation. The rate of crossovers (CO) varies depending upon the taxon, population, age, external conditions, and also, sometimes, between the sexes, a phenomenon called heterochiasmy. In the model plant Arabidopsis thaliana, the male rate of all crossover events (mCO) is typically nearly double the female rate (fCO). A previous, PCR-based genotyping study has reported that the disparity...
Mon Jun 01, 2020 16:14
Calcium (Ca) is an essential plant nutrient, required for signaling, cell wall fortification and growth and development. Calcium deficiency (Ca-deficiency) in maize causes leaf tip rot and a so-called "bull-whipping" or "buggy-whipping" phenotype. Seedlings of the maize line B73 displayed these Ca-deficiency-like symptoms when grown in the greenhouse with excess fertilizer during the winter months, while seedlings of the Mo17 maize line did not display these symptoms under the same conditions. These...
Mon Jun 01, 2020 16:14
Despite its peculiar distribution, the biology of the southernmost bat species in the world, the Chilean myotis (Myotis chiloensis), has garnered little attention so far. The species has a north-south distribution of c. 2800 km, mostly on the eastern side of the Andes mountain range. Use of extended torpor occurs in the southernmost portion of the range, putting the species at risk of bat white-nose syndrome, a fungal disease responsible for massive population declines in North American bats. Here,...
Mon Jun 01, 2020 16:14
It has been hypothesized that androgens respond to the social interactions as a way to adjust the behavior of individuals to the challenges of the social environment in an adaptive manner. Therefore, it is expected that transient changes in circulating androgen levels within physiological scope should impact the state of the brain network that regulates social behavior, which should translate into adaptive behavioral changes. Here, we examined the effect that a transient peak in androgen circulating...
Mon Jun 01, 2020 16:14
Continuous glucose monitorings (CGMs) have been used to manage diabetes with reasonable glucose control amongst patients with type 2 diabetes (T2D) in recent decades. CGMs measure interstitial fluid glucose le...
Sun May 31, 2020 03:00
Chronic musculoskeletal pain represents an enormous burden in society. Best-practice care for chronic musculoskeletal pain suggests adoption of self-management strategies. Telehealth interventions (e.g., video...
Sun May 31, 2020 03:00
Barriers to receiving optimal healthcare exist for Indigenous populations globally for a range of reasons. To overcome such barriers and enable greater access to basic and specialist care, developments in info...
Sun May 31, 2020 03:00
First responders are a high-risk population for occupational stress injuries as they often encounter prolonged stress within their line of work. The aim of this rapid overview of reviews is to summarize existi...
Sun May 31, 2020 03:00
The University of Washington School of Dentistry has announced the full launch of its Virtual Clinic to serve patients remotely. The post School of Dentistry to expand use of remote patient visits appeared first on UW School of Dentistry.
Mon Jun 01, 2020 18:01
Publication date: Available online 31 May 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Ângela Reis-Rego, João Almeida, João Lino
Mon Jun 01, 2020 18:29
Publication date: Available online 31 May 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): João Paulo Mota de Paulo, Felipe Herbert de Oliveira Mendes, Raimundo Thompson Gonçalves Filho, Felipe Franco Marçal
Mon Jun 01, 2020 18:07
AbstractThis study aimed to determine perceptual response differences and characterize desensitization to capsaicin over time across several oral cavity mucosae– the tongue, cheek, hard palate, and lip. For each region, subjects rated the intensity of capsaicin and a vehicle control over a 10-minute period. Following a rest period, capsaicin was reapplied on each pretreated area and subjects indicated which side felt more irritated then rated each side every 30 seconds, over 3.5 minutes. Results...
Mon Jun 01, 2020 03:00
A study was presented in which sarcomas were microinjected simultaneously with several drugs to study the pharmacodynamic response after resection. This platform may represent a future way of probing efficacy of anticancer agents in the relevant model system: human tumors.
Mon Jun 01, 2020 16:17
Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Kevin Campbell, Arlene Naranjo, Emily Hibbitts, Julie M. Gastier-Foster, Rochelle Bagatell, Meredith S. Irwin, Hiroyuki Shimada, Michael Hogarty, Julie R. Park, Steven G. DuBois
Mon Jun 01, 2020 17:26
Publication date: Available online 31 May 2020Source: European Journal of CancerAuthor(s): Alice Indini, Erika Rijavec, Michele Ghidini, Monica Cattaneo, Francesco Grossi
Mon Jun 01, 2020 17:26
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00454E, CommunicationYu Li, Junjun Feng, Yuchen Huang, Yu Qin, Dechen Jiang, Hong-Yuan ChenUpconverting ion-selective nanoparticles are prepared here that emit the light at near-infrared region. The transport of calcium ions induces the deprotonation of the incorporated chromoionophore (P6) through ion exchange resulting...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 01, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00682C, Critical ReviewRachel Alice Hand, Elena Piletska, T. Bassindale, Geraint Morgan, Nicholas TurnerThe problem posed by anti-doping requirements is one of the great analytical challenges; multiple compound detection at low ng ml-1 levels from complex samples, with requirements for exceptional confidence in...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 01, 2020 02:00
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/06/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Jun 01, 2020 17:10
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/06/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Jun 01, 2020 13:04
Publication date: Available online 1 June 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Anouk A.F. Stoffels, Jana De Brandt, Roy Meys, Hieronymus W.H. van Hees, Anouk W. Vaes, Peter Klijn, Chris Burtin, Frits M.E. Franssen, Bram van den Borst, Maurice J.H. Sillen, Emiel F.M. Wouters, Daisy J.A. Janssen, Martijn A. Spruit, BASES consortium
Mon Jun 01, 2020 17:07
Related ArticlesFacilitating heart transplantability in an end-stage heart failure patient with brain abscess and infected left ventricle assist device-A unique case report. Int J Surg Case Rep. 2020 May 22;71:213-216 Authors: Ibrahim M, Arafat S, Rojas SV, Schramm R, Gummert JF, Morshuis M, Fox H Abstract INTRODUCTION: Heart transplantation is the desired therapy in end-stage heart failure (HF) and in patients with left-ventricular assist devices (LVAD)...
Mon Jun 01, 2020 17:02
Related ArticlesEosinophilic gastroenteritis in small intestine in a child in a remote medical centre required surgery. Int J Surg Case Rep. 2020 May 25;71:209-212 Authors: Kakaje A, Hedar N, Alali Alahmad N Abstract INTRODUCTION: Eosinophilic gastroenteritis (EGE) is an extremely rare disease of unknown aetiology that can occur at any age, but rarely in children. It usually presents with ambiguous abdominal pain and the symptoms can occur for years...
Mon Jun 01, 2020 17:02
Related ArticlesPost traumatic left cardiac luxation: A case report. Int J Surg Case Rep. 2020 May 15;71:205-208 Authors: Lajmi M, Ben Ismail I, Ragmoun W, Messaoudi H, Lahdhili H, Chenik S Abstract INTRODUCTION: Rupture of the pericardium complicating blunt thoracic trauma may lead to cardiac luxation if not early recognized and appropriately surgically treated. This condition is exceedingly rare and carries a high mortality rate. CASE PRESENTATION:...
Mon Jun 01, 2020 17:02
Related ArticlesLaparoscopic cholecystectomy in a patient with situs inversus totalis after videolaparoscopic sleeve-Case report. Int J Surg Case Rep. 2020 May 19;71:202-204 Authors: Ponce Leon F, Fiorencio MH, Leal CP, Santos AR Abstract INTRODUCTION: Situs inversus totalis is the technical term used when there is a complete transposition of all organs to the opposite side referring to classical embryogenic orientation. Laparoscopic cholecystectomy...
Mon Jun 01, 2020 17:02
Related ArticlesEvaluation of Subtotal Petrosectomy Technique in Difficult Cases of Cochlear Implantation. Audiol Neurootol. 2020 May 29;:1-13 Authors: Grinblat G, Vlad D, Caruso A, Sanna M Abstract OBJECTIVES: To assess the validity of the subtotal petrosectomy (STP) technique in problematic cases of cochlear implant (CI) surgery, and review indications, outcomes, and related controversies. STUDY DESIGN: This is a retrospective review of data...
Mon Jun 01, 2020 16:56
Related ArticlesEndoscopic Endonasal Approach for Clival Chordoma with Subarachnoid Invasion: a 2D Step-by-Step Operative Video. World Neurosurg. 2020 May 28;: Authors: Albonette-Felicio T, Silveira-Bertazzo GS, Martínez-Pérez R, Shahein M, Zachariah M, Carrau RL, Prevedello DM Abstract Chordomas are slow-growing, low-grade, locally invasive and locally aggressive tumors. They peak at 40 - 60 years of age, with a male preponderance (2:1). Belonging to...
Mon Jun 01, 2020 16:56
Estimation of Pleural Effusion Volume through Chest Ultrasound: Validation of Two Multiplanar Models
Publication date: Available online 1 June 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Simone Scarlata, Ilaria Venditti, Giorgia Fulco, Panaiotis Finamore, Renato Giua, Raffaele Antonelli Incalzi, Sergio Silvestri
Mon Jun 01, 2020 16:54
Publication date: Available online 1 June 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Victor Barrere, David Melodelima, Stefan Catheline, Bruno Giammarinaro
Mon Jun 01, 2020 16:54
Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients
Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria, characterized by small itchy wheals that appear upon physical exercise or passive warming. Malassezia globosa, a skin resident fungus...
Mon Jun 01, 2020 03:00
Related ArticlesmiR-34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ-8073/CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. J Cell Physiol. 2020 May 31;: Authors: Liu X, Zhang L, Yang L, Cui J, Che S, Liu Y, Han J, An X, Cao B, Song Y Abstract microRNAs (miRNAs) and circular RNAs (circRNAs) are important for endometrial receptivity establishment and embryo implantation in mammals. miR-34a and miR-34c are highly expressed...
Mon Jun 01, 2020 16:38
Related ArticlesThe proinflammatory cytokines IL-1β and TNF-α modulate corneal epithelial wound healing through p16Ink4a suppressing STAT3 activity. J Cell Physiol. 2020 May 31;: Authors: Wang X, Zhang S, Dong M, Li Y, Zhou Q, Yang L Abstract The proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are involved in the corneal inflammatory response and wound healing following corneal injuries. However, the mechanism by...
Mon Jun 01, 2020 16:38
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