First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Jing Liu is first author on ‘Advanced oxidation protein products change biological behaviors of rat endometrial epithelial cells by activating ERK/P38 signaling pathways’, published in BiO. Jing is a doctor in the lab of Yali Song at the Center for Reproductive Medicine, Department of Obstetrics and Gynecology,...
5m
Jing Liu, Sixi Wen, Yanling Lin, Xiaoping Yang, Zebang Liu, Song Quan, and Yali SongAdvanced oxidation protein products (AOPPs) are a family of oxidized protein compounds and could induce oxidative stress and inflammatory lesion in various cells. The accumulation of AOPPs was associated with female reproductive diseases such as polycystic ovary syndrome (PCOS), leiomyoma and endometriosis. However, the relationship between AOPPs and endometrial cells is unclear. To explore the effects of accumulated...
5m
Xin Hou, Xiaowen Chen, He Yang, Wucheng Yue, Jun Wang, Hua Han, and Chenghui WangVacuolar ATPase (V-ATPase) is a proton pump driven by ATP hydrolysis, and it plays an important role in numerous biological processes, such as protein degradation and synthesis, cell growth, and cell autophagy. The V-ATPase subunit B (VATB) is a conservative and regulatory subunit required for ATP hydrolysis during proton pumping. The VATB of Eriocheir sinensis (EsVATB), which includes an open reading frame (ORF) length...
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Akash Gupta, Geetanjali Gupta, Rajeshwari R. Mehta, David Z. Ivancic, Rashidra R. Walker, Jankiben R. Patel, Karen M. Gallegos, A. Michael Davidson, Seema A. Khan, Rajendra G. Mehta, and Syreeta L. TilghmanMouse mammary organ culture (MMOC) is used to evaluate the efficacy of chemopreventive agents against the development of carcinogen-induced preneoplastic lesions and is highly correlative to in vivo carcinogenesis models. Here, we developed a new ex vivo MMOC model, by introducing human breast...
5m
Deng-Tai Wen, Wei-Qing Wang, Wen-Qi Hou, Shu-Xian Cai, and Shuai-Shuai ZhaiA high-salt diet (HSD) is a major cause of many chronic and age-related defects such as myocardial hypertrophy, locomotor impairment and mortality. Exercise training can efficiently prevent and treat many chronic and age-related diseases. However, it remains unclear whether endurance exercise can resist HSD-induced impairment of climbing capacity and longevity in aging individuals. In our study, flies were given exercise...
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First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Deng-Tai Wen is first author on ‘Endurance exercise protects aging Drosophila from high-salt diet (HSD)-induced climbing capacity decline and lifespan decrease by enhancing antioxidant capacity’, published in BiO. Deng-Tai conducted the research described in this article while a PhD student in the sports science-exercise,...
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First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Akash Gupta is first author on ‘A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture’, published in BiO. Akash conducted the research described in this article while a PhD Scholar in Rajendra Mehta's lab at IIT Research Institute, Chicago,...
5m
Xi Cheng, Manli Li, Dahui Li, Jinyun Zhang, Qing Jin, Lingling Sheng, Yongping Cai, and Yi Lin
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Longhao Li, Chundong Zhang, Yi Li, Ying Zhang, and Yunlong LeiTumor metastasis is the main contributor to high recurrence and mortality in colorectal cancer (CRC). In a previous study, we found that DJ-1 plays an important role in CRC metastasis, and is the main target in Ciclopirox olamine (CPX)-treated CRC. However, the mechanism underlying DJ-1-induced CRC metastasis remains elusive. In the present study, our results showed that DJ-1 could activate Wnt signaling resulting in enhanced invasive...
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First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Hao Lu is first author on ‘ Reissner fiber-induced Urotensin signaling from CSF-contacting neurons prevents scoliosis of the vertebrate spine’, published in BiO. He is a Research Fellow in the laboratory of Dr Sudipto Roy at the Institute of Molecular and Cell Biology in Singapore, using the zebrafish and mouse...
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Hao Lu, Aidana Shagirova, Julian L. Goggi, Hui Li Yeo, and Sudipto RoyReissner fibre (RF), discovered by the 19th-century German anatomist Ernst Reissner, is a filamentous structure present in cerebrospinal fluid (CSF). RF forms by aggregation of a glycoprotein called SCO-spondin (Sspo), but its function has remained enigmatic. Recent studies have shown that zebrafish sspo mutants develop a curved embryonic body axis. Zebrafish embryos with impaired cilia motility also develop curved bodies, which...
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Thomas Weber, Lars Schlotawa, Roland Dosch, Noemie Hamilton, Jens Kaiser, Stina Schiller, Britta Wenske, Jutta Gärtner, and Marco HennekeHuman infantile-onset RNASET2-deficient cystic leukoencephalopathy is a Mendelian mimic of in utero cytomegalovirus brain infection with prenatally developing inflammatory brain lesions. We used an RNASET2-deficient zebrafish model to elucidate the underlying disease mechanisms. Mutant and wild-type zebrafish larvae brain development between 2 and 5 days post...
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Paul J. Vorster, Paul Goetsch, Tilini U. Wijeratne, Keelan Z. Guiley, Laura Andrejka, Sarvind Tripathi, Braden J. Larson, Seth M. Rubin, Susan Strome, and Joseph S. LipsickThe five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB-family tumor suppressor proteins and E2F-DP transcription factors to form DREAM complexes that repress genes that regulate cell cycle progression and cell fate. The MuvB core complex also interacts with Myb family oncoproteins...
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First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Chiara Herzog and David Greenald are co-first authors on ‘RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo’, published in BiO. Chiara is associate business development manager at BioClavis Ltd, Queen Elizabeth University...
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Chiara Herzog, David Greenald, Juan Larraz, Marcus Keatinge, and Leah HerrgenUnderstanding the molecular mechanisms that regulate secondary cell death after acute central nervous system (CNS) injury is critical for the development of effective neuroprotective drugs. Previous research has shown that neurotoxic processes including excitotoxicity, oxidative stress and neuroinflammation can cause secondary cell death. Nevertheless, clinical trials targeting these processes have been largely unsuccessful,...
5m
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Tamsin Samuels is first author on ‘ Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation’, published in BiO. Tamsin conducted the research described in this article while a DPhil (PhD) student in Professor Ilan Davis's lab at the Department...
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Tamsin J. Samuels, Yoav Arava, Aino I. Järvelin, Francesca Robertson, Jeffrey Y. Lee, Lu Yang, Ching-Po Yang, Tzumin Lee, David Ish-Horowicz, and Ilan DavisDuring Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation. Prospero level is low in neural stem cells and their immediate progeny, but is upregulated in larval neurons and it is unknown how this process is controlled....
5m
Susana Ponte, Lara Carvalho, Maria Gagliardi, Isabel Campos, Paulo J. Oliveira, and Antonio JacintoMitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is linked to several human diseases. In this work, we investigated the role of mitochondrial dynamics in wound healing in the Drosophila embryonic epidermis....
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Abstract In this study, lactic acid bacteria strains (LABs) were isolated from Korean traditional fermented food and examined as potential probiotics using in vitro methods. Ten LAB strains survived in de Man, Rogosa and Sharpe broth adjusted to pH 2.5 were tested for resistance to acidic conditions and bile, antimicrobial activity, and α-glucosidase inhibitory activity. Among them, strain MBEL1397 showed antimicrobial activity against Bacillus cereus and exhibited survival rates...
17m
Aortic carboxypeptidase-like protein (ACLP) is a collagen-binding extracellular matrix (ECM) protein that has important roles in wound healing and fibrosis. ACLP contains thrombospondin repeats, a collagen-binding discoidin domain, and a catalytically inactive metallocarboxypeptidase domain. Recently, mutations in the ACLP-encoding gene, AE-binding protein 1 (AEBP1), have been discovered, leading to the identification of a new variant of Ehlers–Danlos syndrome (EDS) causing connective tissue disruptions...
35m
Compartmentalization of macromolecules is a ubiquitous molecular mechanism that drives numerous cellular functions. Appropriate organization of enzymes in space and time enables the precise transmission and integration of intracellular signals. Molecular scaffolds constrain signaling enzymes to influence the regional modulation of these physiological processes. Mitochondrial targeting of protein kinases and protein phosphatases provides a means to locally control the phosphorylation status and action...
36m
Intracellular collagen assembly begins with the oxidative folding of ~30-kDa C-terminal propeptide (C-Pro) domains. Folded C-Pro domains then template the formation of triple helices between appropriate partner strands. Numerous C-Pro missense variants that disrupt or delay triple-helix formation are known to cause disease, but our understanding of the specific proteostasis defects introduced by these variants remains immature. Moreover, it is unclear whether or not recognition and quality control...
36m
Aortic dissection is a life-threatening aortopathy involving separation of the aortic wall, whose underlying mechanisms are still incompletely understood. Epidemiological evidence suggests that unsaturated fatty acids improve cardiovascular health. Here, using quantitative RT-PCR, histological analyses, magnetic cell sorting and flow cytometry assays, and mass spectrometry-based lipidomics, we show that the activity of a lipid-metabolizing enzyme, secreted phospholipase A2 group V (sPLA2-V), protects...
36m
Polycomb group (PcG) proteins are essential for maintenance of lineage fidelity by coordinating developmental gene expression programs. Polycomb group ring finger 6 (PCGF6) has been previously reported to repress expression of lineage-specific genes, especially germ cell–related genes in mouse embryonic stem cells (ESCs) via the non-canonical polycomb repressive complex PRC1.6. However, the molecular mechanism of this repression remains largely unknown. Here, using RNA-Seq, real-time RT-PCR, immunohistochemistry,...
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COVID-19 — A TIMELINE OF THE CORONAVIRUS OUTBREAK Dec. 31, 2019Chinese authorities inform WHO’s China office of pneumonia cases in Wuhan City, Hubei province, China, with unknown cause Jan. 1, 2020Officials close the Huanan seafood market, suspected to be the source of the mystery disease Jan. 7, 2020China identifies new coronavirus as cause of the outbreak Jan. 9, 2020China reports first death linked to 2019-nCoV. A 61-year-old male in Wuhan with several...
1h
Asthma is a chronic airway inflammation disease that is frequently found in children and adolescents with an increasing prevalence. Several studies are linking its presence to many lifestyle and health correla...
2h
Abstract The objective of this study was to determine whether snacks containing curcumin have beneficial effects on dog health. The snacks were produced from commercial canned meat for dogs, and curcumin was added and homogenized. Snacks containing 15 mg of curcumin were produced, frozen, and offered to dogs twice a day. Ten beagles (6 months of age) were used. The animals were placed in an experimental kennel and allocated randomly to 1 of 2 treatments (5 dogs/treatment): snacks...
3h
Abstract Aims The objective of this study is to compare size, enamel thickness and ion relative concentration in generalized megadontia (Ekman- Westborg and Julin trait) and a localized megadont upper third molar to normal teeth. Materials and methods The MD dimensions of permanent teeth were compared to controls. Tooth components of molars were measured...
3h
ACS NanoDOI: 10.1021/acsnano.0c01054
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ACS NanoDOI: 10.1021/acsnano.9b08268
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We sought to investigate the safety and efficacy of stereotactic body radiation therapy (SBRT) for isolated local recurrence after surgical resection of non-small cell lung cancer (NSCLC). Forty-eight patients were treated with salvage SBRT. Median follow was 22.6 months showing excellent local control and minimal toxicity. Salvage SBRT outcomes were similar to definitive treatment of NSCLC with SBRT.
3h
To investigate the permeability changes and the mechanisms of fractured rock under dynamic and static stresses produced by earthquakes, permeability experiments on fractured rock with rough surfaces under axial dynamic and static stresses were conducted on the MTS815 Rock Mechanics Testing System. Surface asperity was investigated by scanning the specimen surfaces before and after testing. The results show that the roughness of fracture surface has a great influence on the permeability when the axial...
3h
A structural analysis method is proposed in this paper for cable-beam composite structure with a large number of cable elements; it can improve computational efficiency and accuracy. Firstly, we use a structural division method to divide the whole cable-beam structure into inner cablenet system and edge cablenet-beam system. Because inner cablenet is a pure cablenet structure with given shape and topology, balance matrix analysis method is used to help obtain the best pretension distribution of it...
3h
Background. A Percutaneous Balloon Pericardiotomy (PBP) procedure is a reemerging nonsurgical technique that helps in preventing the reaccumulation of pericardial effusion. It is done percutaneously without general anaesthesia. It has been proved to be effective in alleviating and preventing recurrent pericardial effusion. Case Presentation. We reported a 52-year-old male with stage IV adenocarcinoma causing recurrent pericardial effusion. The patient experienced a worsening shortness of breath....
3h
Objective. Nowadays, trans-sacral epiduroscopic laser decompression (SELD) using slender epiduroscopy and laser is one of the preferred options for minimally invasive treatment in lumbar disc diseases. However, SELD is still in the initial stages of the global field of spine surgery, and the clinical outcomes in patients with lumbar disc herniation are not established yet. Therefore, the authors investigated patients undergoing SELD to report the clinical results. Methods. Between November 2015 and...
3h
Introduction. Intersigmoid hernia is a hernia of the small bowel into the intersigmoid fossa. It is well known to be a rare condition. Recent reports reveal that the preoperative differentiation of intersigmoid hernias is difficult and the diagnosis is often confirmed during the laparotomic exploration. Due to the vague clinical manifestation in most cases, the surgical treatment is frequently delayed. Materials and Methods. In this study, we systematically reviewed the literature up to 2019 covering...
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Wogonin (5,7-dihydroxy-8-methoxyflavone) is an ingredient of the extracts from Scutellaria baicalensis, which has documented a wide spectrum of anti-inflammatory and antitumor activities, including inhibiting regulatory T cells, regulating effector T cell functions, and mediating macrophage immunity. However, the potential effect of Wogonin on B cells has not been fully understood. Here, our results showed that Wogonin inhibited IL-10 secretion in B cells. When purified B cells were activated by...
3h
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