Abstract Advance directives (AD) are the possibility for any individual to express their wishes on how to be cared at the end of life, when they can no longer make the decisions themselves. In France, AD are only applicable during the end‐of‐life period, such as after an irrecoverable accident or at a terminal phase of a disease. It appeared for the first time in France in 2005 with the Léonetti law, which discussed matters related to the end of life.
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Abstract Postinfarction ventricular septal rupture is a rare and devastating complication of myocardial infarction. Despite attempts at acute surgical and percutaneous defect closure, morbidity and mortality remain high. Herein, we describe a hybrid surgical and catheter‐based approach to defect closure in a 63‐year‐old woman with postinfarction ventricular septal rupture and cardiogenic shock.
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Abstract Background Bleeding complications and acute limb ischemia (ALI) are devastating vascular complications in patients with ST‐segment elevation myocardial infarction (STEMI). Cardiogenic shock (CS) can further increase this risk due to multiorgan failure. In the contemporary era, percutaneous mechanical circulatory support is commonly used for management of CS. We hypothesized that vascular complications may be an important determinant of clinical outcomes for CS due to STEMI (CS‐STEMI)....
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Abstract Background Use of drug coated balloons (DCBs) in coronary intervention is escalating. There is a plethora of data on Paclitaxcel‐DCB. However, when it comes of stents, Limus‐drugs are preferred over Paclitaxel. There is very limited data on Sirolimus coated balloons (SCB). MagicTouch‐SCB (Concept Medical, FL) elutes Sirolimus via nano‐technology and have been used in our centers since March 2018. We report a mid‐term follow‐up with this relatively novel‐technology. Methods and results...
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Abstract COVID‐19 is a new viral infection that has a significant impact on global health and economy. Because of its rapid spread worldwide, it may influence the prognosis of other medical conditions, such as ST‐segment elevation myocardial infarction (STEMI). We report a case of a 58‐year female patient admitted with an infero‐posterior STEMI on the background of recently positive COVID‐19 swab. Reperfusion was attempted through primary PCI but unfortunately failed to restore coronary blood flow...
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Abstract We describe a patient presenting with chest discomfort, anterolateral ST elevation, and developing acute cardiogenic shock secondary to SARS‐COV‐2infection—patient zero presenting to our institution's cardiac catheterization laboratory. The emergent presentation with limited clinical information led to exposure of personnel. The diagnosis was complicated by two negative tests for SARS‐COV‐2, and high‐clinical suspicion from the patient's occupational history led to additional testing in...
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Cancers, Vol. 12, Pages 1422: Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective? Cancers doi: 10.3390/cancers12061422 Authors: Plaz Torres Bodini Furnari Marabotto Zentilin Strazzabosco Giannini Hepatocellular carcinoma (HCC), the most frequent primary liver cancer, is the sixth most common cancer, the fourth leading cause of cancer-related deaths worldwide, and accounts globally for...
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Cancers, Vol. 12, Pages 1423: Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma Cancers doi: 10.3390/cancers12061423 Authors: Ramzy Koessler Ducrey McKee Ris Buchs Rubbia-Brandt Dietrich Nowak-Sliwinska Lack of relevant preclinical models that reliably recapitulate the complexity and heterogeneity of human cancer has slowed down the development and approval of new anti-cancer therapies. Even though two-dimensional...
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Abstract Universities in Nigeria aim to be on global map with better international rankings. Unfortunately, they are plagued with inefficient administration and management due to poor management of records and information. Universities, most of the cases are failed to comply with the National Universities Commission, which resulted higher possibilities of revoking their licenses. The need for effective records and information management is imperative. Information Governance deals...
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Cancers, Vol. 12, Pages 1419: Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12061419 Authors: Sangineto Villani Cavallone Romano Loizzi Serviddio : Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However,...
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Cancers, Vol. 12, Pages 1420: Targeted Osmotic Lysis of Highly Invasive Breast Carcinomas Using Pulsed Magnetic Field Stimulation of Voltage-Gated Sodium Channels and Pharmacological Blockade of Sodium Pumps Cancers doi: 10.3390/cancers12061420 Authors: Paul Maggi Piero Scahill Sherman Edenfield Gould Abstract: Concurrent activation of voltage-gated sodium channels (VGSCs) and blockade of Na+ pumps causes a targeted osmotic lysis (TOL) of carcinomas...
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Cancers, Vol. 12, Pages 1421: Galectins and Ovarian Cancer Cancers doi: 10.3390/cancers12061421 Authors: Chisa Shimada Rui Xu Linah Al-Alem Marina Stasenko David R. Spriggs Bo R. Rueda Ovarian cancer is known for its aggressive pathological features, including the capacity to undergo epithelial to mesenchymal transition, promoting angiogenesis, metastatic potential, chemoresistance, inhibiting apoptosis, immunosuppression and promoting stem-like features. Galectins,...
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Health care workers at the city hospital hit hardest by the pandemic go beyond their job description in tending to a vulnerable population -- Read more on ScientificAmerican.com
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Rejuvenation Research, Ahead of Print.
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Telemedicine and e-Health, Ahead of Print.
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Levosimendan is effective in the therapy of chronic heart failure in both mature and old rats, but the duration of its therapeutic effect differs in these age groups. In 15 days after treatment, the myocardium in old rats maintained augmented functionality, whereas in old animals, functional potencies returned to the levels observed prior to the therapy. Stimulation of tissue respiration with combined administration of L-carnitine and α-lipoic acid against the background of levosimendan treatment...
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Intranasal administration of antibodies to glutamate in a dose of 250 μg/kg for two weeks facilitated spatial learning and memory formation in the Morris water maze in aging C57BL/6 mice. In animals treated with glutamate antibodies, the content of serotonin and dopamine metabolites 3-MT and HVA in the hippocampus decreased, but no changes in the metabolism of neurotransmitter acids were revealed. In the prefrontal cortex, dopamine level decreased and the content of its metabolite DOPAC increased;...
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We analyzed the role of opioid receptors in the conditioning effect of continuous normobaric hypoxia on bioenergetics of the heart subjected to ischemia/reperfusion injury. Male Wistar rats were adapted to a 21-day continuous normobaric hypoxia (12% pO2). Then, the hearts were isolated and subjected to 45-min total ischemia followed by 30-min reperfusion. Damage to the myocardium was assessed by activity of creatine phosphokinase in the perfusate. Experiments on isolated mitochondria showed that...
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The effects of anti-orthostatic hypokinesia on the parameters of vertical posture (orthostatic and postural stability) were studied. Anti-orthostatic hypokinesia was followed by orthostatic instability manifested in a decrease in the tolerance time in the orthostatic test, a significant increase in HR and systolic BP starting from the 11th minute of the test. Significant changes in the parameters reflecting postural stability were observed starting from minutes 10-11 of the stabilometric test. Anti-orthostatic...
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Health and risk management of personnel in hot climates remains a Commander’s responsibility, with Joint Service Publication 539 Heat Illness and Cold Injury: Prevention and Management (JSP 539) being the guiding document for the UK military. This policy can be challenging to interpret occasionally, needing medical professionals to provide ongoing advice to commanders. This is to achieve a shared understanding of scientific concepts and risks to allow a more informed decision-making by commanders....
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Visual standards for military aviators were historically set in the 1920s with requirements based on the visual systems of aircraft at the time, and these standards have changed very little despite significant advances in aircraft technology. Helmet-mounted displays (HMDs) today enable pilots to keep their head out of the cockpit while flying and can be monocular, biocular or binocular in design. With next generation binocular HMDs, flight data can be displayed in three-dimensional stereo to declutter...
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IntroductionTrauma centre capacity and surge volume may affect decisions on where to transport a critically injured patient and whether to bypass the closest facility. Our hypothesis was that overcrowding and high patient acuity would contribute to increase the mortality risk for incoming admissions.MethodsFor a 6-year period, we merged and cross-correlated our institutional trauma registry with a database on Trauma Resuscitation Unit (TRU) patient admissions, movement and discharges, with average...
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BackgroundThe prevalence of civilian 0.223 ammunition is widespread. Due to low costs and the same dimensions as a 5.56x45 mm North Atlantic Treaty Organization, this round is exceptionally popular. However, recent mass shootings have employed soft point (SP) expanding ammunition to cause grievous wounds compared with military full metal jacket (FMJ) rounds that do not rapidly expand on impact.MethodsThe aim of this given study is to compare FMJ and SP rounds to determine if there are diagnostic...
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ObjectiveAfter deployment, service members can experience difficulties reintegrating. Sustaining injuries on the battlefield can disrupt the reintegration period. The first aim was to follow-up the reintegration attitude towards family, work and on a personal level after deployment in Dutch battlefield casualties (BCs). The second was to compare their postdeployment reintegration attitude with that of healthy controls.MethodsA questionnaire concerning reintegration attitude, the Postdeployment Reintegration...
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IntroductionThis paper presents the burden of mental health cases throughout UK military exercise SAIF SAREEA 3 (SS3), a low-tempo armoured brigade exercise in Oman from June to November 2018, and aims to discuss ways that mental health may be better managed on future large exercises.MethodsA retrospective review of all attendances at army medical facilities and relevant computerised medical records was undertaken.Results14 mental health cases were identified, which required 51 follow-up presentations...
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IntroductionEpidemiological data captured from military exercises and operations can highlight treatment requirements specific to operating in certain environmental conditions. Such data is invaluable to enable accurate planning for future exercises. Epidemiological data were collected during Exercise SAIF SAREEA 3 (SS3) to provide an insight into medical provision requirements for low-tempo military operations in hot, desert climates.MethodEpidemiological data was collected from all consultations...
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Abstract Background Esophageal squamous cell carcinoma (ESCC) and leiomyoma are common tumors. The coexistence of these two tumors can be classified into two types: the overlying type and the separate type. The overlying type is rare. Methods We report 12 cases of the overlying type treated by endoscopic submucosal dissection (ESD). They underwent pre-ESD...
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Despite the existence of several metrics to perform measurements on out-of-order packets, few works have used these metrics for comparative purposes. A potential reason for this is that the use of these simple singleton metrics makes it difficult to analyze all the effects of packet reordering. On the other hand, more complete metrics are represented in a vectorial manner, making comparative analysis challenging. In this paper, we present a scenario for testing and describe a methodology for conducting...
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Replicating acceleration time histories with high accuracy on shaking table platforms is still a challenging task. The complex interference between the components of the system, the inherent nonlinearities, and the coupling effect between the specimen and the shaking table are among other reasons that most affect the control performance. In this paper, a neural network- (NN-) based controller has been developed and experimentally implemented to improve the acceleration tracking performance of an...
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Seismic evaluation of underground structures such as tunnels requires nonlinear dynamic analysis, due to the complex dynamic behavior of soil and the interaction of soil and structure. Simulation of the seismic response of the structure using nonlinear dynamic analysis is possible only with proper acceleration time history. Considering the vertical component of the earthquake (such as near-fault earthquakes) on the site is an important factor to achieve real structural responses. In the current study,...
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In the real-time position technology of underground shallow source, the signal denoising performance of wireless sensor nodes directly determines the location speed and accuracy of underground burst point. Because of the complexity and randomness of the underground medium and the fact that underground explosion is a nonstationary transient process, the problems of low convergence rate and poor steady-state performance of the filter exist when the existing LMS algorithm is used for signal denoising....
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The penetration-explosion warhead is one of the most effective weapons for use against concrete structures. In order to study the phenomena and results for concrete damage caused by the combined effects of penetration and explosion, field experiments were performed on damaged concrete targets with different penetration speeds and explosive charges. The damage to the targets was analyzed, the causes were determined, and prediction methodologies were developed. Dimensional analysis was used to fit...
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This article presents analytical solutions to the problem of dynamic stress concentration and the surface displacement of a partially debonded cylindrical inclusion in the covering layer under the action of a steady-state horizontally polarized shear wave (SH wave); these solutions are using the complex function method and wave function expansion method. By applying the large-arc assumption method, the straight line boundary of the half-space covering layer is transformed into a curved boundary....
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In this study, the potential for pulverized raw macadamia nut shell (MNS) for the sequestration of methylene blue from aqueous media was assessed. The sorbent was characterized using scanning electron microscopy for surface morphology, functional group analysis was performed with a Fourier-transform infrared spectrometer (FT-IR), and Brunauer–Emmett–Teller (BET) isotherm was used for surface area elucidation. The effects of contact time, sorbent dosage, particle size, pH, and change in a solution...
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Automatically detecting mud in bauxite ores is important and valuable, with which we can improve productivity and reduce pollution. However, distinguishing mud and ores in a real scene is challenging for their similarity in shape, color, and texture. Moreover, training a deep learning model needs a large amount of exactly labeled samples, which is expensive and time consuming. Aiming at the challenging problem, this paper proposed a novel weakly supervised method based on deep active learning (AL),...
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Objective. The risk to dentists, assistants, and patients of infectious diseases through aerosols has long been recognized. The aim of this study was to evaluate and compare the efficacy of commercially available preprocedural mouth rinses containing 0.2% chlorhexidine (CHX) gluconate, Befresh™ herbal mouthwash, and water in reducing the levels of viable bacteria in aerosols. Materials & Methods. This was a single-center, double-masked, placebo-controlled, randomized, three-group parallel design...
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With the deepening of electricity market (EM) reform and the high penetration of photovoltaic (PV) energy in power system, the uncertainties of a PV power output and fluctuation of EM prices would bring substantial financial risks for PV power producers (PPPs). This paper proposed a robust optimization model for PPP’s power bidding decision-making. Specifically, the random PV power outputs are modeled by the uncertainty set, which need no probabilistic information and can fully depict the continuous...
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To profile the landscape of methylation N6 adenosine (m6A) RNA regulators in colonic adenocarcinoma (COAD) and to explore potential diagnostic and prognostic biomarkers, we assessed the differential expression patterns of m6A RNA methylation regulators between 418 COAD patients and 41 controls based on profiling from The Cancer Genome Atlas (TCGA) database. We plotted the receiver operating characteristic (ROC) curves and calculated the area under the curve (AUC) values to estimate the discrimination...
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