Related ArticlesStapes Surgery Outcomes in Patients With Concurrent Otosclerosis and Superior Semicircular Canal Dehiscence. Otol Neurotol. 2020 May 28;: Authors: McClellan J, Nguyen A, Hamilton B, Jethanamest D, Hulla TE, Gupta S Abstract OBJECTIVE: To review outcomes of stapes surgery in patients with concurrent otosclerosis and superior semicircular canal dehiscence. STUDY DESIGN: Retrospective case series. SETTING:: Tertiary...
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Related ArticlesOutcomes of Revision Cochlear Implantation. Otol Neurotol. 2020 May 28;: Authors: Kimura KS, O'Connell BP, Nassiri AM, Dedmon MM, Haynes DS, Bennett ML Abstract OBJECTIVES/HYPOTHESIS: This study aims to 1) report revision cochlear implantation (CI) rates at a high-volume CI center, 2) describe classifications for revision CI, 3) analyze audiologic and surgical outcomes in patients who undergo revision CI, and 4) describe a new subcategory...
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Related ArticlesTympanoplasty With or Without Balloon Eustachian Tuboplasty for Chronic Suppurative Otitis Media With Obstructive Eustachian Tube Dysfunction. Otol Neurotol. 2020 May 28;: Authors: Hsieh CY, Chang CJ, Sun CH, Lee CY, Gotamco GL, Hsu CJ, Wu HP Abstract OBJECTIVE: To further elucidate the role of balloon Eustachian tuboplasty (BET) in tympanoplasty, we conducted a study to compare the outcomes of tympanoplasty with and without BET for...
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Related ArticlesPatient-specific 3D-printed Model-assisted Supracochlear Approach to the Petrous Apex. Otol Neurotol. 2020 May 28;: Authors: Takahashi K, Morita Y, Aizawa N, Ogi M, Nonomura Y, Kitazawa M, Yagi C, Ohshima S, Izumi S, Yamagishi T, Horii A Abstract OBJECTIVE: To present a case of pediatric cholesteatoma that invaded the petrous apex (PA) and discuss the usefulness of preoperative three-dimensional (3D) surgical simulation on a personal...
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Related ArticlesDiagnosis of Stapedial Myoclonus Using Endoscopic Visualization. Otol Neurotol. 2020 May 28;: Authors: Barber SR, Barbarite E, Corrales CE Abstract BACKGROUND: Stapedial myoclonus is an uncommon condition involving the rhythmic contraction of the stapedial tendon that may result in a host of symptoms, including tinnitus (1-3). There is a dearth of robust diagnostic modalities to diagnose stapedial myoclonus(4-7), and most patients...
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Related ArticlesTranscutaneous Electrical Nerve Stimulation for Treatment of Tinnitus: A Systematic Review and Meta-Analysis. Otol Neurotol. 2020 May 28;: Authors: Byun YJ, Lee JA, Nguyen SA, Rizk HG, Meyer TA, Lambert PR Abstract OBJECTIVE: To evaluate the treatment efficacy of transcutaneous electrical nerve stimulation (TENS) in patients with tinnitus. DATA SOURCES: PubMed, Scopus, Web of Science, and Cochrane Library were searched for...
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Related ArticlesCOVID-19 Pandemic and Otologic Surgery. J Craniofac Surg. 2020 May 28;: Authors: Cetinkaya EA Abstract All around world, the COVID-19 pandemic is accelerating, and any insight we can learn from our colleagues who have either encountered or are currently going through this will be used to protect our patients, our medical staff, and ourselves. No one knows to the best of our understanding whether or not COVID-19 includes the respiratory...
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Related ArticlesWe Know About COVID-19: Oral and Maxillofacial Surgeons Survey. J Craniofac Surg. 2020 May 28;: Authors: Costa SM, Lacerda GT, Villafort RN, Silveira RL, Amaral MBF Abstract Coronavírus disease 2019 (COVID-19) is a virus of mass dissemination, with an impact on international public health, leading to hospitalizations and death. The main symptoms of COVID-19 are fever, fatigue, dry cough; however, myalgia and dyspnea and the transmission...
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Related ArticlesPostauricular Island Flap in Reconstruction of Auricula Tumor Defects. J Craniofac Surg. 2020 May 28;: Authors: Mehel DM, Özdemir D, Çelebi M, Saraç N, Aydemir S, Özgür A Abstract The most common malignant tumor in humans is skin cancers. Skin cancers are most commonly seen in the head and neck region due to direct exposure to sunlight. Most frequently seen skin cancer in the auricula are basal cell carcinoma (BCC) and squamous cell...
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Related ArticlesGiant Ventral Lipoma of the Neck. J Craniofac Surg. 2020 May 28;: Authors: Woo SJ, Hong KY, Chang H Abstract Giant lipomas are rarely found in the head and neck region. A 67-year-old male patient presented with a massive ventral swelling of his neck extending from the lower margin of the mandible to the clavicle. The mass had slowly grown over 20 years without causing any symptoms, except for considerable psychological stress because...
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Related ArticlesMethod for Safely Excising a Large Head and Neck Arteriovenous Malformation in the Hybrid Operating Room. J Craniofac Surg. 2020 May 28;: Authors: Pessino KA, Ortiz RA, Bastidas N Abstract Large head and neck arteriovenous malformations are notoriously difficult to manage given their location and propensity for extreme hemorrhage. We propose a unique approach utilizing a Hyperform balloon and percutaneous Surgiflo sclerotherapy to...
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Related ArticlesProgression of squamous cell carcinoma is regulated by miR-139-5p/CXCR4. Front Biosci (Landmark Ed). 2020 Jun 01;25:1732-1745 Authors: Jiang Q, Cao Y, Qiu Y, Li C, Liu L, Xu G Abstract miR-139-5p has a tumor suppressor effect in some cancers and negatively regulates CXCR4. To this end, we examined the expression and mechanism of of action of miR-139-5p and CXCR4 in oral squamous cell carcinoma (OSCC). miRNA-139-5p was down-regulated...
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Related ArticlesAdherence of head and neck squamous cell carcinoma patients to tumor board recommendations. Cancer Med. 2020 May 30;: Authors: Rangabashyam MS, Lee SY, Tan SY, Mueller S, Sultana R, Ho J, Skanthakumar T, Tan NC, Tan HK, Soo KC, Iyer NG Abstract BACKGROUND: Multidisciplinary team (MDT) meetings or tumor boards (TBs) are fundamental components of cancer treatment. Although their primary function is improved outcomes, this aspect is...
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Related ArticlesLong-term outcomes of skull base chordoma treated with high-dose carbon-ion radiotherapy. Head Neck. 2020 May 30;: Authors: Koto M, Ikawa H, Kaneko T, Hagiwara Y, Hayashi K, Tsuji H Abstract BACKGROUND: We evaluated the long-term efficacy and safety of carbon-ion radiotherapy (C-ion RT) for skull base chordoma, a rare neoplasm. METHODS: Thirty-four patients with skull base chordoma who were treated with C-ion RT were prospectively...
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Related ArticlesVentilated Upper Airway Endoscopic Endonasal Procedure Mask: Surgical Safety in the COVID-19 Era. Oper Neurosurg (Hagerstown). 2020 May 30;: Authors: Helman SN, Soriano RM, Tomov ML, Serpooshan V, Levy JM, Pradilla G, Solares CA Abstract BACKGROUND: COVID-19 poses a risk to the endoscopic skull base surgeon. Significant efforts to improving safety have been employed, including the use of personal protective equipment, preoperative...
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Related ArticlesFamilial cancer risk in family members and spouses of patients with early-onset head and neck cancer. Head Neck. 2020 May 30;: Authors: Mroueh R, Tanskanen T, Haapaniemi A, Salo T, Malila N, Mäkitie A, Pitkäniemi J Abstract BACKGROUND: Reported patterns of familial aggregation of head and neck cancer (HNC) vary greatly, with many studies hampered by the limited number of subjects. METHODS: Altogether 923 early-onset (≤40 years...
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Related ArticlesCOVID-19 Pandemic and Surgical Oncology: Preserving the Academic Mission. Ann Surg Oncol. 2020 May 29;: Authors: Pawlik TM, Tyler DS, Sumer B, Meric-Bernstam F, Okereke IC, Beane JD, Dedhia PH, Ejaz A, McMasters KM, Tanabe KK Abstract BACKGROUND: The global pandemic of respiratory disease cause by the novel human coronavirus (SARS-CoV-2) has caused untold suffering, loss of life and upheaval in society. The pandemic has lead to massive...
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Related ArticlesMapping the microbiological diversity of odontogenic abscess: are we using the right drugs? Clin Oral Investig. 2020 May 29;: Authors: Heim N, Jürgensen B, Kramer FJ, Wiedemeyer V Abstract OBJECTIVES: The aim of this study was categorizing the microbial flora and susceptibility to antibiotics and to clarify to which degree the empiric administered antibiotics are suitable for therapy. MATERIALS AND METHODS: A 3.5-year retrospective...
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Related Articles[Noninvasive evaluation of airways prior to sedation or anesthesia : An update within the framework of the revision of the German S1 guidelines on airway management 2015 of the German Society for Anesthesiology and Intensive Care Medicine]. Anaesthesist. 2020 May 29;: Authors: Ilper H, Kunz T, Faißt M Abstract As a single and reliable parameter for prediction of the difficult airway is missing, the specialist societies for anesthesiology...
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Related ArticlesThe interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway. Cell Death Dis. 2020 May 29;11(5):405 Authors: Xu Q, Ma H, Chang H, Feng Z, Zhang C, Yang X Abstract Interleukin-8 (IL-8) expression correlates with poor prognosis in many cancers, including head and neck squamous cell carcinoma (HNSCC), but the underlying mechanism is poorly understood....
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Related ArticlesThe positive correlation between Porphyromonas gingivalis and Prevotella spp. Response to: 'Comment on 'Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population' by Kishikawa et al.' by Kitamura et al. Ann Rheum Dis. 2020 May 29;: Authors: Kishikawa T, Maeda Y, Nii T, Okada Y PMID: 32471897 [PubMed - as supplied by publisher]
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Related ArticlesDiagnostic Tests for SARS-CoV-2: Implications in Head and Neck Oncology. Oral Oncol. 2020 May 21;:104813 Authors: Kochhar AS, Bhasin R, Kochhar GK, Dadlani H PMID: 32471801 [PubMed - as supplied by publisher]
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Related ArticlesCochlear implantation after traumatic brain injury without otic capsule fracture: A case report and literature review. Am J Otolaryngol. 2020 Apr 30;:102512 Authors: Lindquist NR, Stapp M, Choi JS, Lovin BD, Sweeney AD Abstract OBJECTIVE: The aim of this study was to report a case of cochlear implantation (CI) for a patient with an otic capsule-sparing traumatic brain injury (TBI) and to review the relevant literature. METHODS:...
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Related ArticlesSARS-CoV-2: Naso-bronchial cytological correlations. Am J Otolaryngol. 2020 May 26;:102549 Authors: Gelardi M, Notargiacomo M, Trecca EMC, Cassano M PMID: 32471774 [PubMed - as supplied by publisher]
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Related Articles[Ten years of advances in head and neck surgery, how does this influence postoperative radiotherapy?] Bull Cancer. 2020 May 26;: Authors: Thariat J, Leleu T, Micault E, Gery B, Bastit V, Jeanne C, Humbert M, Dugas A, Le Guevelou J, Florescu C, Patron V, Lasne-Cardon A, Babin E Abstract Minimal invasive surgery and reconstructive surgery tend to become the standard in France in the management of head and neck tumors. The use of endoscopic...
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Related ArticlesTinnitus Neuroimaging. Otolaryngol Clin North Am. 2020 May 26;: Authors: Adams ME, Huang TC, Nagarajan S, Cheung SW Abstract This article reviews the use of human neuroimaging for chronic subjective tinnitus. Evidence-based guidance on the clinical use of imaging to identify relevant auditory lesions when evaluating tinnitus patients is given. After introducing the anatomy and imaging modalities most pertinent to the neuroscience...
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Related ArticlesUnusual presentation of a first Branchial cleft cyst associated with an abnormal bony canal -a case report. J Otolaryngol Head Neck Surg. 2020 May 29;49(1):32 Authors: Fanous A, Couloigner V, Gorphe P, Galmiche L, Alexandru M, Garabedian EN, Coffinet L, Blanc T, Leboulanger N, Denoyelle F Abstract BACKGROUND: First branchial cleft anomalies are rare, accounting for only 10% of all branchial cleft anomalies. We report an even more...
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Related ArticlesPrognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis. J Otolaryngol Head Neck Surg. 2020 May 29;49(1):31 Authors: Abdeyrim A, He S, Zhang Y, Mamtali G, Asla A, Yusup M, Liu J Abstract BACKGROUND: Several recent studies have indicated that the lymph node ratio (LNR) is an independent prognostic factor for laryngeal and hypopharyngeal squamous cell carcinoma...
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Related ArticlesRadiation therapy is an important factor to improve survival in pediatric patients with head and neck rhabdomyosarcoma by enhancing local control: a historical cohort study from a single center. BMC Pediatr. 2020 May 29;20(1):265 Authors: Wen Y, Huang D, Zhang W, Zhang Y, Hu H, Li J Abstract BACKGROUND: The purpose of this study is to analyze the influence of radiation therapy on survival in a historical cohort of 56 pediatric patients...
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Related ArticlesThe Tumor Suppressor TGFBR3 Blocks Lymph Node Metastasis in Head and Neck Cancer. Cancers (Basel). 2020 May 27;12(6): Authors: Fang WY, Kuo YZ, Chang JY, Hsiao JR, Kao HY, Tsai ST, Wu LW Abstract The TGF-β type III receptor (TGFBR3) is an essential constituent of the TGF-β signaling. In this study, we observed a down-regulation of TGFBR3 in oral cancer, a subtype of head and neck cancer (HNC), and patients with low TGFBR3 had poor...
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Cancers, Vol. 12, Pages 1429: Baseline Splenic Volume as a Prognostic Biomarker of FOLFIRI Efficacy and a Surrogate Marker of MDSC Accumulation in Metastatic Colorectal Carcinoma Cancers doi: 10.3390/cancers12061429 Authors: Julie Niogret Emeric Limagne Marion Thibaudin Julie Blanc Aurelie Bertaut Karine Le Malicot Yves Rinaldi François-Xavier Caroli-Bosc Franck Audemar Suzanne Nguyen Corinne Sarda Catherine Lombard-Bohas Christophe Locher...
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Cancers, Vol. 12, Pages 1427: The Recombinant Fragment of Human κ-Casein Induces Cell Death by Targeting the Proteins of Mitochondrial Import in Breast Cancer Cells Cancers doi: 10.3390/cancers12061427 Authors: Max Richter Fabian Wohlfromm Thilo Kähne Hannes Bongartz Kamil Seyrek Yuriy Kit Olga Chinak Vladimir A. Richter Olga A. Koval Inna N. Lavrik Breast cancer is still one of the most common cancers for women. Specified therapeutics are indispensable...
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Cancers, Vol. 12, Pages 1424: Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer Cancers doi: 10.3390/cancers12061424 Authors: Toshihiko Takeiwa Kazuhiro Ikeda Yuichi Mitobe Kuniko Horie-Inoue Satoshi Inoue Long noncoding RNAs (lncRNAs) are defined as RNAs longer than 200 nucleotides that do not encode proteins. Recent studies have demonstrated that numerous lncRNAs are expressed in humans and play key roles in the development of various...
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Cancers, Vol. 12, Pages 1428: Benefits of Conversion Surgery after Multimodal Treatment for Unresectable Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12061428 Authors: Yanagimoto Satoi Yamamoto Yamaki Hirooka Kotsuka Ryota Ishida Matsui Sekimoto Background: Traditionally, the treatment options for unresectable locally advanced (UR-LA) and metastatic (UR-M) pancreatic ductal adenocarcinoma (PDAC) are palliative chemotherapy...
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Cancers, Vol. 12, Pages 1430: Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer Cancers doi: 10.3390/cancers12061430 Authors: Marlène Deschuyter Florian Pennarubia Emilie Pinault Sébastien Legardinier Abderrahman Maftah Background: Protein O-fucosyltransferase 1 (POFUT1) overexpression, which is observed in many cancers such as colorectal cancer (CRC), leads to a NOTCH signaling dysregulation associated with the tumoral process. In...
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Cellular transformation into myofibroblasts is a central physiological process enabling tissue repair. Its deregulation promotes fibrosis and carcinogenesis. TGF-β is the main inducer of the contractile gene program that drives myofibroblast differentiation from various precursor cell types. Crucial regulators of this transcriptional program are serum response factor (SRF) and its cofactor MKL1 (also known as MRTF-A). However, the exact mechanism of the crosstalk between TGF-β signaling and MKL1...
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Alagille syndrome (AGS) is a multisystem disorder classically involving liver and heart failure, characteristic vertebral and facial features and ocular abnormalities. AGS is caused by heterozygous mutations in JAG1 or NOTCH2, with variable phenotype penetrance. We report two cases of AGS in children with tooth defects characterised by green discolouration and hypomineralisation. The role of hyperbilirubinaemia (HB) in this atypical colour, a classical feature of AGS, has been well described. However,...
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Irinotecan is a novel anticancer drug that has worked wonders in combination with other anticancer drugs. It can be used as a single chemotherapy agent in colonic cancer treatment or in combination with 5-fluorouracil. Irinotecan has been found a better salvage therapy in patients who are resistant to 5-fluorouracil. It is also used in combination with cisplatin and other drugs for cancers such as pleural mesothelioma, Ewing’s sarcoma, lung cancer and others, and has helped reduce tumour burden....
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Idiopathic intracranial hypertension typically presents with holocephalic headache associated with nausea, vomiting and bilateral papilledema. Involvement of the sixth cranial nerve is relatively common. The involvement of other cranial nerves, however, is rare in this disorder. We describe a patient with idiopathic intracranial hypertension who presented with episodic unilateral retro-orbital pain and multiple cranial nerve abnormalities without papilledema. Imaging studies excluded alternate diagnoses,...
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