Current status and prospect of translational medicine in nanotechnology
Author(s): GAO Guang-yu, CHEN Mei-ling, LI Ming-yuan, YANG Zhen-bo, LI Zhi-ping, MEI Xing-guo, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
Journal: Acta Pharmaceutica Sinica, Year 2015 , Issue 8 , Page 919-924
Keyword: nanotechnology; bio-medical; nanotoxicity; translational medicine;
Abstract: Nowadays, nanotechnologies have shown wide application foreground in the biomedical field of medicine laboratory tests, drug delivery, gene therapy and bioremediation. However, in recent years, nanomaterials have been labeled poisonous, because of the disputes and misunderstandings of mainstream views on their safety. Besides, for the barriers of technical issues in preparation like: low efficacy(poor PK & 1 PD and low drug loading), 2high cost(irreproducibility and difficulty in scale up), little of that research has been successfully translated into commercial products. Currently, along with the new theory of "physical damage is the origin of nanotoxicity", biodegradability and biocompatibility of nanomaterials are listed as the basic principle of safe application of nanomaterials. Combining scientific design based on molecular level with precision control of process engineering will provide a new strategy to overcome the core technical challenges. New turning point of translational medicine in nanotechnology may emerge.
http://caod.oriprobe.com/articles/46356289/Current_status_and_prospect_of_translational_medic.htm
Author(s): GAO Guang-yu, CHEN Mei-ling, LI Ming-yuan, YANG Zhen-bo, LI Zhi-ping, MEI Xing-guo, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
Journal: Acta Pharmaceutica Sinica, Year 2015 , Issue 8 , Page 919-924
Keyword: nanotechnology; bio-medical; nanotoxicity; translational medicine;
Abstract: Nowadays, nanotechnologies have shown wide application foreground in the biomedical field of medicine laboratory tests, drug delivery, gene therapy and bioremediation. However, in recent years, nanomaterials have been labeled poisonous, because of the disputes and misunderstandings of mainstream views on their safety. Besides, for the barriers of technical issues in preparation like: low efficacy(poor PK & 1 PD and low drug loading), 2high cost(irreproducibility and difficulty in scale up), little of that research has been successfully translated into commercial products. Currently, along with the new theory of "physical damage is the origin of nanotoxicity", biodegradability and biocompatibility of nanomaterials are listed as the basic principle of safe application of nanomaterials. Combining scientific design based on molecular level with precision control of process engineering will provide a new strategy to overcome the core technical challenges. New turning point of translational medicine in nanotechnology may emerge.
http://caod.oriprobe.com/articles/46356289/Current_status_and_prospect_of_translational_medic.htm
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