The role of heat shock protein 70 in regulating neuroinflammation
Author(s): YU Wen-wen, BAO Xiu-qi, SUN Hua, ZHANG Dan, State Key Laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Journal: Acta Pharmaceutica Sinica, Year 2015 , Issue 8 , Page 945-950
Keyword: heat shock protein 70; neuroinflammation; nuclear transcription factor kappa B; neurodegenerative disease;
Abstract: Neurodegenerative disease is characterized by progressive loss of neurons in specific brain regions that results in neuronal dysfunction of the central nervous system. Although the pathological mechanism is not fully established, the activation of glial cells mediated neuroinflammation appears to be involved. Heat shock protein 70(HSP70) is originally described as intracellular chaperone, which plays an important role in protein quality control in cells. However, recent study showed that up-regulation of HSP70 had anti-inflammatory effects in the brain. HSP70 protected neurons from damage and improved neurological function by decreasing inflammatory response as indicated by inactivation of glial cells and inhibition of pro-inflammatory cytokine release. So it is of great significance to find new compounds targeting at HSP70 as neuroprotective agents to delay the progress of neurodegenerative disease. This review will focus on the role of HSP70 in neuroinflammation and the recent advances in using HSP70 as a target for the treatment of neurodegenerative disease.
http://caod.oriprobe.com/articles/46356272/The_role_of_heat_shock_protein_70_in_regulating_ne.htm
Author(s): YU Wen-wen, BAO Xiu-qi, SUN Hua, ZHANG Dan, State Key Laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Journal: Acta Pharmaceutica Sinica, Year 2015 , Issue 8 , Page 945-950
Keyword: heat shock protein 70; neuroinflammation; nuclear transcription factor kappa B; neurodegenerative disease;
Abstract: Neurodegenerative disease is characterized by progressive loss of neurons in specific brain regions that results in neuronal dysfunction of the central nervous system. Although the pathological mechanism is not fully established, the activation of glial cells mediated neuroinflammation appears to be involved. Heat shock protein 70(HSP70) is originally described as intracellular chaperone, which plays an important role in protein quality control in cells. However, recent study showed that up-regulation of HSP70 had anti-inflammatory effects in the brain. HSP70 protected neurons from damage and improved neurological function by decreasing inflammatory response as indicated by inactivation of glial cells and inhibition of pro-inflammatory cytokine release. So it is of great significance to find new compounds targeting at HSP70 as neuroprotective agents to delay the progress of neurodegenerative disease. This review will focus on the role of HSP70 in neuroinflammation and the recent advances in using HSP70 as a target for the treatment of neurodegenerative disease.
http://caod.oriprobe.com/articles/46356272/The_role_of_heat_shock_protein_70_in_regulating_ne.htm
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