Research on single nucleotide polymorphism with initial anticoagulative effect and maintenance dose of Warfarin
Author(s): WU Jiong, LI Jun, WU Shengchao, ZHANG Chunyan, SONG Binbin, WANG Beili, GUO Wei, PAN Baishen, Department of Clinical Laboratory, Zhongshan Hospital, Fudan University School of Medicine, Cardial Surgery, Zhongshan Hospital, Fudan University School of Medicine
Journal: Shanghai Journal of Medical Laboratory Sciences, Year 2015 , Issue 7 , Page 707-714
Keyword: Warfarin; Single nucleotide polymorphism; Initial anticoagulative effect; Maintenance dose;
Abstract: Objective To screen genetic factors influencing Warfarin initial anticoagulative effect and maintenance dose. Methods A total of 212 Chinese Han mechanical heart valve replacement patients were enrolled as initial anticoagulative effect group. △INR4-1[the difference between international normalized ratio( INR) at the end of observation and initial INR] was used as an index to screen genetic factors during 4 d after their operations. The obtained results were needed to be identified whether they were associated with other endpoint events like overanticoagulation( INR > 3 and INR > 4) and time to first therapeutic INR in 3 d. In the maintenance dose group,266 Chinese Han outpatients who had been taking Warfarin for over 3 months were enrolled. Warfarin maintenance dose was defined as the dose that led to the patients' INR within the therapeutic range measured at least 7 d,which was used to screen genetic factors. Results In the initial anticoagulative effect group,CYP2C9( rs1057910),VKORC1( rs9923231) and VKORC1( rs2292566) were associated with △INR4-1( P < 0. 05),and CYP2C9( rs1057910) and EPHX1( rs2292566) were associated with time to first therapeutic INR( P < 0. 001,P < 0. 05). In the maintenance dose group,CYP2C9( rs1057910) and VKORC1( rs9923231) were associated with daily and weekly maintenance doses( P < 0. 05). Conclusions CYP2C9( rs1057910),VKORC1( rs9923231) and EPHX1( rs2292566) show strongly association with Warfarin initial anticoagulative effect. CYP2C9( rs1057910) and VKORC1( rs9923231) are significant factors for maintenance dose.
http://caod.oriprobe.com/articles/46334914/Research_on_single_nucleotide_polymorphism_with_in.htm
Author(s): WU Jiong, LI Jun, WU Shengchao, ZHANG Chunyan, SONG Binbin, WANG Beili, GUO Wei, PAN Baishen, Department of Clinical Laboratory, Zhongshan Hospital, Fudan University School of Medicine, Cardial Surgery, Zhongshan Hospital, Fudan University School of Medicine
Journal: Shanghai Journal of Medical Laboratory Sciences, Year 2015 , Issue 7 , Page 707-714
Keyword: Warfarin; Single nucleotide polymorphism; Initial anticoagulative effect; Maintenance dose;
Abstract: Objective To screen genetic factors influencing Warfarin initial anticoagulative effect and maintenance dose. Methods A total of 212 Chinese Han mechanical heart valve replacement patients were enrolled as initial anticoagulative effect group. △INR4-1[the difference between international normalized ratio( INR) at the end of observation and initial INR] was used as an index to screen genetic factors during 4 d after their operations. The obtained results were needed to be identified whether they were associated with other endpoint events like overanticoagulation( INR > 3 and INR > 4) and time to first therapeutic INR in 3 d. In the maintenance dose group,266 Chinese Han outpatients who had been taking Warfarin for over 3 months were enrolled. Warfarin maintenance dose was defined as the dose that led to the patients' INR within the therapeutic range measured at least 7 d,which was used to screen genetic factors. Results In the initial anticoagulative effect group,CYP2C9( rs1057910),VKORC1( rs9923231) and VKORC1( rs2292566) were associated with △INR4-1( P < 0. 05),and CYP2C9( rs1057910) and EPHX1( rs2292566) were associated with time to first therapeutic INR( P < 0. 001,P < 0. 05). In the maintenance dose group,CYP2C9( rs1057910) and VKORC1( rs9923231) were associated with daily and weekly maintenance doses( P < 0. 05). Conclusions CYP2C9( rs1057910),VKORC1( rs9923231) and EPHX1( rs2292566) show strongly association with Warfarin initial anticoagulative effect. CYP2C9( rs1057910) and VKORC1( rs9923231) are significant factors for maintenance dose.
http://caod.oriprobe.com/articles/46334914/Research_on_single_nucleotide_polymorphism_with_in.htm
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