The Changes and Clinical Significance of Serum TNF- α、IL-6 and NSE in Patients after Cardiopulmonary Resuscitation
Author(s): HE Jing-zhao, LI Shao-hong, YAO Yi-ming, Department of Emergency, Tung wah Hosipital Affiliated to Sun Yat-sen University
Journal: Lingnan Journal of Emergency Medicine, Year 2015 , Issue 3 , Page 175-177
Keyword: cardiopulmonary resuscitation; tumor necrosis factors-α; interleukin-6; neuron-specific enolase;
Abstract: Objective :To explore the change and clinical significance of serum tumor necrosis factors- α(TNF-α)、interleukin-6(IL-6) and neuron-specific enolase(NSE)in patients after cardiopulmonary resuscitation(CPR).Methods: The levels of serum TNF-α、IL-6 and NSE at each time point in 26 patients after CPR were measured by ELISA. Results :The levels of serum TNF-α 、IL-6 and NSE gradually increased in patients after CPR,the peak value of serum TNF-α appeared at 24 hours after CPR,the peak value of serum IL-6 and NSE appeared at 48 hours after CPR. The serum IL-6 levels were positively correlated with serum TNF-αlevels(P<0.01),and the serum NSE levels were positively correlated with serum TNF-αand IL-6 levels(P<0.01). Conclusion :TNF-α、IL-6 may be involved in the pathological damage process of patients after CPR,and brain injury severity may be closely associated with the levels of serum TNF-α、IL-6 in patients after CPR.
http://caod.oriprobe.com/articles/46351839/The_Changes_and_Clinical_Significance_of_Serum_TNF.htm
Author(s): HE Jing-zhao, LI Shao-hong, YAO Yi-ming, Department of Emergency, Tung wah Hosipital Affiliated to Sun Yat-sen University
Journal: Lingnan Journal of Emergency Medicine, Year 2015 , Issue 3 , Page 175-177
Keyword: cardiopulmonary resuscitation; tumor necrosis factors-α; interleukin-6; neuron-specific enolase;
Abstract: Objective :To explore the change and clinical significance of serum tumor necrosis factors- α(TNF-α)、interleukin-6(IL-6) and neuron-specific enolase(NSE)in patients after cardiopulmonary resuscitation(CPR).Methods: The levels of serum TNF-α、IL-6 and NSE at each time point in 26 patients after CPR were measured by ELISA. Results :The levels of serum TNF-α 、IL-6 and NSE gradually increased in patients after CPR,the peak value of serum TNF-α appeared at 24 hours after CPR,the peak value of serum IL-6 and NSE appeared at 48 hours after CPR. The serum IL-6 levels were positively correlated with serum TNF-αlevels(P<0.01),and the serum NSE levels were positively correlated with serum TNF-αand IL-6 levels(P<0.01). Conclusion :TNF-α、IL-6 may be involved in the pathological damage process of patients after CPR,and brain injury severity may be closely associated with the levels of serum TNF-α、IL-6 in patients after CPR.
http://caod.oriprobe.com/articles/46351839/The_Changes_and_Clinical_Significance_of_Serum_TNF.htm
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