The Research of Small-dose Neostigmine Antagonizing Low Level Residual Paralysis in Elderly Patients after Surgery
Author(s): CHEN Zhi-cong, PENG Jun, BAO Ya-nan, SHI Jia-hua, HUANG Shao-nong, LIU Zhi-heng, Department of Anesthesiology, the Second People 's Hosptial of Shenzhen, Sun Yat-sen Memorial Hosptial, Sun Yat-sen University
Journal: Lingnan Journal of Emergency Medicine, Year 2015 , Issue 3 , Page 211-213
Keyword: elderly patients; residual paralysis; antagonize; neostigmine; cisatracurium;
Abstract: Objective :To explore the effect relationship of small-dose neostigmine antagonizing low level residual paralysis(TOFR =0.7) induced by cisatracurium in elderly patients after surgery. Methods : 80 elderly patients scheduled for elective surgery were enrolled and randomly assigned into 4 groups,each group was 20 cases. When the Train-of-Four Ratio(TOFR) returned to 0.7 after surgery, 5 μg / kg, 10 μg / kg and 20 μg / kg neostigmine dissolved in 0.9% normal saline 3ml and 0.9% normal saline 3 ml were administered intravenously in group S5,group S10,group S20 and group S0, respectively. Then,time needed for TOFR to 1.0 was recorded,the success rate of full reversal within 10 minutes was calculated,heart rate(HR) and blood pressure(BP) were recorded just before administration and 3 min, 5 min and 10 min after administration. Postoperative nausea and vomiting within 6 h in each group were compared. Results :Time needed for TOFR to 1.0 in group S10 and group S20 were significantly less than that in group S0(5.0 min vs 13.0 min and 2.5 min vs 13.0 min respectively,P<0.01). The success rates of full reversal in group S10 and group S20 were significantly increased(P<0.05) when compared to group S0. HR in group S20 was significantly lower at 3 min,5 min and 10 min after administration when compared to the value recorded just before drug administration(P<0.05). There were no statistical differences in PONV among all the groups within 6 h(P>0.05). Conclusion : When given at TOFR 0.7 in elderly patients after surgery, 10μg / kg neostigmine was needed for successful reversal the residual paralysis of cisatracurium within 10 min, with no influences on the heart rate and incidence of PONV.
http://caod.oriprobe.com/articles/46351822/The_Research_of_Small_dose_Neostigmine_Antagonizin.htm
Author(s): CHEN Zhi-cong, PENG Jun, BAO Ya-nan, SHI Jia-hua, HUANG Shao-nong, LIU Zhi-heng, Department of Anesthesiology, the Second People 's Hosptial of Shenzhen, Sun Yat-sen Memorial Hosptial, Sun Yat-sen University
Journal: Lingnan Journal of Emergency Medicine, Year 2015 , Issue 3 , Page 211-213
Keyword: elderly patients; residual paralysis; antagonize; neostigmine; cisatracurium;
Abstract: Objective :To explore the effect relationship of small-dose neostigmine antagonizing low level residual paralysis(TOFR =0.7) induced by cisatracurium in elderly patients after surgery. Methods : 80 elderly patients scheduled for elective surgery were enrolled and randomly assigned into 4 groups,each group was 20 cases. When the Train-of-Four Ratio(TOFR) returned to 0.7 after surgery, 5 μg / kg, 10 μg / kg and 20 μg / kg neostigmine dissolved in 0.9% normal saline 3ml and 0.9% normal saline 3 ml were administered intravenously in group S5,group S10,group S20 and group S0, respectively. Then,time needed for TOFR to 1.0 was recorded,the success rate of full reversal within 10 minutes was calculated,heart rate(HR) and blood pressure(BP) were recorded just before administration and 3 min, 5 min and 10 min after administration. Postoperative nausea and vomiting within 6 h in each group were compared. Results :Time needed for TOFR to 1.0 in group S10 and group S20 were significantly less than that in group S0(5.0 min vs 13.0 min and 2.5 min vs 13.0 min respectively,P<0.01). The success rates of full reversal in group S10 and group S20 were significantly increased(P<0.05) when compared to group S0. HR in group S20 was significantly lower at 3 min,5 min and 10 min after administration when compared to the value recorded just before drug administration(P<0.05). There were no statistical differences in PONV among all the groups within 6 h(P>0.05). Conclusion : When given at TOFR 0.7 in elderly patients after surgery, 10μg / kg neostigmine was needed for successful reversal the residual paralysis of cisatracurium within 10 min, with no influences on the heart rate and incidence of PONV.
http://caod.oriprobe.com/articles/46351822/The_Research_of_Small_dose_Neostigmine_Antagonizin.htm
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